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Multiple Evanescent White Dot Syndrome Following COVID-19 mRNA Vaccination.
Gargouri, Mohamed Ali; Yousfi, Naoufel; Toutain, Jonathan; Farès, Selim; Lejoyeux, Raphaël; Gabison, Eric; Cochereau, Isabelle; Titah, Cherif; Azar, Georges.
  • Gargouri MA; Ophthalmology Department, Rothschild Foundation Hospital, Paris, France.
  • Yousfi N; Ophthalmology Department, Rothschild Foundation Hospital, Paris, France.
  • Toutain J; Ophthalmology Department, Rothschild Foundation Hospital, Paris, France.
  • Farès S; Ophthalmology Department, Rothschild Foundation Hospital, Paris, France.
  • Lejoyeux R; Ophthalmology Department, Rothschild Foundation Hospital, Paris, France.
  • Gabison E; Ophthalmology Department, Rothschild Foundation Hospital, Paris, France.
  • Cochereau I; Ophthalmology Department, Rothschild Foundation Hospital, Paris, France.
  • Titah C; Ophthalmology Department, Rothschild Foundation Hospital, Paris, France.
  • Azar G; Ophthalmology Department, Rothschild Foundation Hospital, Paris, France.
Ocul Immunol Inflamm ; : 1-5, 2022 Oct 13.
Article in English | MEDLINE | ID: covidwho-2062599
ABSTRACT

PURPOSE:

To report two cases of multiple evanescent white dot syndrome (MEWDS) following COVID-19 vaccination with the BNT162b2 mRNA vaccine.

METHODS:

Two case reports. Case-1 A 40-yo Caucasian male, complained of blurred and decrease of vision in his left eye (OS) one week after the first dose of the BNT162b2 mRNA SARS-CoV-2 vaccine. Funduscopic examination OS showed multiple granular white dots with an aspect of foveal granularity. Case-2 A 23-yo woman also presented with defective and decrease of vision OS. She received her first dose of the BNT162b2 mRNA SARS-CoV-2 vaccine ten days before. Dilated fundus examination OS showed altered macular reflex with an aspect of foveal granularity.

RESULTS:

Multimodal imaging showed features of MEWDS in both cases. The anomalies found resolved spontaneously after 6 weeks.

CONCLUSION:

Inflammation and immune dysregulation induced by COVID-19 mRNA vaccine or its adjuvants could be involved in ocular adverse effects.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal: Ocul Immunol Inflamm Journal subject: Allergy and Immunology / Ophthalmology Year: 2022 Document Type: Article Affiliation country: 09273948.2022.2127782

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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal: Ocul Immunol Inflamm Journal subject: Allergy and Immunology / Ophthalmology Year: 2022 Document Type: Article Affiliation country: 09273948.2022.2127782