Multiomics analysis of male infertility.
Biol Reprod
; 107(1): 118-134, 2022 07 25.
Article
in English
| MEDLINE | ID: covidwho-2062863
ABSTRACT
Infertility affects 8-12% of couples globally, and the male factor is a primary cause in ~50% of couples. Male infertility is a multifactorial reproductive disorder, which can be caused by paracrine and autocrine factors, hormones, genes, and epigenetic changes. Recent studies in rodents and most notably in humans using multiomics approach have yielded important insights into understanding the biology of spermatogenesis. Nonetheless, the etiology and pathogenesis of male infertility are still largely unknown. In this review, we summarized and critically evaluated findings based on the use of advanced technologies to compare normal and obstructive azoospermic versus nonobstructive azoospermic men, including whole-genome bisulfite sequencing, single-cell RNA-seq, whole-exome sequencing, and transposase-accessible chromatin using sequencing. It is obvious that the multiomics approach is the method of choice for basic research and clinical studies including clinical diagnosis of male infertility.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Azoospermia
/
Infertility, Male
Type of study:
Etiology study
/
Experimental Studies
/
Prognostic study
Limits:
Humans
/
Male
Language:
English
Journal:
Biol Reprod
Year:
2022
Document Type:
Article
Affiliation country:
Biolre
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