Acute Cellular Rejection in Liver Transplant Recipients Following Vaccination Against Covid-19
American Journal of Transplantation
; 22(Supplement 3):560-561, 2022.
Article
in English
| EMBASE | ID: covidwho-2063387
ABSTRACT
Purpose:
The coronavirus disease 2019 (COVID-19) global pandemic has seen the development of effective vaccines in record time. We report a series of five liver transplant (LT) recipients who developed acute cellular rejection (ACR) after receiving COVID-19 vaccinations. Method(s) We performed a single-center, retrospective review of LT recipients who presented with biopsy-proven ACR after receiving a COVID-19 vaccination. Result(s) 603 LT recipients were fully vaccinated against COVID-19 at our center on 10/4/2021. Five (0.77%) patients developed elevated liver enzymes after COVID-19 vaccination without an identifiable cause and had a subsequent liver biopsy consistent with ACR four (80%) patients were male and the median age was 54 years old. The indication for LT was cirrhosis secondary to non-alcoholic steatohepatitis in three (60%) and alcohol in two (40%) patients. The median time from LT to the first dose of COVID-19 vaccination was 19 months (range 7-26 months). Three (60%) patients had moderate (RAI= 5/9) ACR. All patients were treated with high-dose intravenous methylprednisolone for 3 days and had normalization of liver enzymes. No patients required rescue therapy with anti-thymocyte globulin or developed graft failure. All patients eventually completed their vaccination series. Conclusion(s) LT recipients may be at risk for developing ACR after the COVID-19 vaccination. Further study is required to better understand this relationship while closer monitoring following vaccination may be warranted in this patient population. (Figure Presented).
acute graft rejection; adult; conference abstract; coronavirus disease 2019; drug megadose; drug therapy; female; graft failure; human; hypertransaminasemia; intravenous drug administration; liver biopsy; liver cirrhosis; liver graft; major clinical study; male; middle aged; nonalcoholic steatohepatitis; retrospective study; surgery; vaccination; alcohol; liver enzyme; methylprednisolone; thymocyte antibody
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Topics:
Vaccines
Language:
English
Journal:
American Journal of Transplantation
Year:
2022
Document Type:
Article
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