Successful Implementation of a Rural Appalachian Kidney Transplant Program, One Year Outcomes
American Journal of Transplantation
; 22(Supplement 3):1110, 2022.
Article
in English
| EMBASE | ID: covidwho-2063405
ABSTRACT
Purpose:
Kidney transplantation has become the optimal treatment for end stage renal disease (ESRD), allowing dialysis free survival. Despite widespread availability of transplant programs;rural patients have limited access to transplantation due to several barriers including increased travel time and financial burden. We report outcomes after establishment of a kidney transplant program serving rural West Virginia. Method(s) A retrospective review of the first 15 kidney transplants performed at a newly established Appalachian transplant program was conducted. Primary outcomes measured were graft survival and function. Other outcomes included graft rejection, patient survival and complications. Data related to patient demographics, etiology of ESRD, type of renal replacement therapy, time on transplant waitlist and average travel to transplant center were also collected. Result(s) The first 15 kidneys transplanted had an overall death censored graft survival rate of 100%. Median patient age was 53 (Range 31- 73 years) and a median follow-up of 6 months (Range 1-13 months). The average time on dialysis for this cohort was 4 years (n=13, Range 1-6 years) and average time on waitlist was 4.06 months (Range 0.4-13.2 months). The most common type of dialysis was hemodialysis (77%) followed by peritoneal dialysis (15%). Two patients were predialysis. Diabetes with hypertension (20%), IgA nephropathy (13%) and diabetes without hypertension (13%) were the most common causes of ESRD. Median graft creatinine was 1.51 mg/dL (Range 1.26 - 1.83 mg/dL) with a glomerular filtration rate (GFR) at 51.38 (Range 41.86-70) at one year. One patient developed acute antibody mediated rejection and one developed borderline T cell mediated rejection (13.3%), which were successfully treated with steroids, plasmapheresis and immune globulin therapy. Two patients died (13.3 %);one from acute respiratory failure following coronavirus (COVID-19) infection and one from cardiac arrest secondary to myocarditis (possible COVID-19). Patients experienced COVID-19 infection at a rate of 13.3 %. The average distance patients had to travel was 94 miles (Range 12 - 164 miles) with a travel time of 1 hour and 52 minutes on average (Range 20 minutes - 2.5 hours) to reach the transplant center. Conclusion(s) We report comparable outcomes from our new rural transplant program despite several barriers to delivery of quality care to our population.
acute respiratory failure; adult; aged; antibody mediated rejection; case report; child; clinical article; cohort analysis; complication; conference abstract; coronavirus disease 2019; demographics; diabetes mellitus; drug therapy; end stage renal disease; female; follow up; glomerulus filtration rate; graft rejection; graft survival; heart arrest; hemodialysis; human; human tissue; hypertension; immunoglobulin A nephropathy; infant; kidney graft; male; middle aged; myocarditis; outcome assessment; overall survival; peritoneal dialysis; plasmapheresis; renal replacement therapy; retrospective study; surgery; T lymphocyte; travel; West Virginia; creatinine; human immunoglobulin; steroid
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
American Journal of Transplantation
Year:
2022
Document Type:
Article
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