SARS-CoV-2 Antibodies Transitions After Vaccination in Solid Organ Transplant Recipients: Multicenter Study in Japan

ABSTRACT

Purpose: For purpose of SARS-CoV-2 infection control, vaccination was started in worldwide, however, low reactivity of antibody production after vaccination is a concern for solid organ transplant (SOT) recipients. In general, antibody titers would be peaked within one month after vaccination for the healthy population, there are few report about SOT recipients vaccination. We explored antibody transitions in SOT recipients after vaccination. Method(s) A total of 641 solid organ transplant recipients were enrolled (481 kidney, 51 liver, 54 heart, 20 lung, and 35 simultaneous pancreas-kidney). All participants were administered the two-dose regimen mRNA vaccine (BNT162b2, Pfizer or mRNA-1273, Moderna), as indicated. SARS-CoV-2 antibodies were measured total 5 times throughout vaccination (Elecsys, Roche). Result(s) The antibody titer and positive rate were both elevated until three months and declined at six months after vaccination (positive rate;10.4%, 41.2%, 68.6%, 56.9%, in each) (Fig.1). Lung and kidney-pancreas transplant recipients showed poor antibody titer elevation compared with other organ transplantation (Fig. 2). Antibody titers be significant low by more than 60 years old compared with other ages (Fig.3). Conclusion(s) The antibody titer and positive rate transition of SOT recipients were quite different compared with the health population. The acquisition of antibody was different depends on type of SOT. (Figure Presented).