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Fixed drug eruptions - the common and novel culprits since 2000.
McClatchy, Jessica; Yap, Tami; Nirenberg, Alexander; Scardamaglia, Laura.
  • McClatchy J; Dermatology Department, The Royal Melbourne Hospital, Melbourne, Australia.
  • Yap T; Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Australia.
  • Nirenberg A; Dermatology Department, The Royal Melbourne Hospital, Melbourne, Australia.
  • Scardamaglia L; Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Australia.
J Dtsch Dermatol Ges ; 20(10): 1289-1302, 2022 10.
Article in English | MEDLINE | ID: covidwho-2063672
ABSTRACT
A fixed drug eruption (FDE) is a common cutaneous adverse drug reaction which occurs following administration of an offending drug. The aim of this review is to provide an update on the list of drugs causing FDE, with a focus on emerging drug culprits reported since the start of the century. Across published literature, triggers for FDE are widely varied. The most frequently implicated drugs include analgesics (nonsteroidal anti-inflammatory drugs [NSAIDs] and paracetamol) and antibiotics. Co-trimoxazole is perhaps the most well described single agent. Since the start of the century there have been over 200 drugs named in case reports on FDE. Newer, novel agents of note include cyclooxygenase-2 specific inhibitors, fluconazole, and phosphodiesterase 5 inhibitors. Other implicated drugs include vaccines, such as various SARS-CoV-2 vaccines. Drugs incriminated in FDE vary based on the geographical region studied and prescribing patterns at a given time. Newer drugs continue to enter the market and are playing an increasing role in the field of FDE. Awareness of rarer culprits and emerging novel agents can help identify a trigger, allowing for prompt withdrawal of the causative agent, preventing recurrence.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Drug Eruptions / COVID-19 Vaccines / COVID-19 Type of study: Diagnostic study Topics: Vaccines Limits: Humans Language: English Journal: J Dtsch Dermatol Ges Journal subject: Dermatology Year: 2022 Document Type: Article Affiliation country: Ddg.14870

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Drug Eruptions / COVID-19 Vaccines / COVID-19 Type of study: Diagnostic study Topics: Vaccines Limits: Humans Language: English Journal: J Dtsch Dermatol Ges Journal subject: Dermatology Year: 2022 Document Type: Article Affiliation country: Ddg.14870