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Dietary supplements for aggressive behaviour in people with intellectual disabilities: A randomised controlled crossover trial.
Gast, David A A; Didden, Robert; Westera, Johanna J; van de Rest, Ondine; van Hemert, Albert M; Giltay, Erik J.
  • Gast DAA; Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
  • Didden R; Gemiva-SVG Group, Gouda, The Netherlands.
  • Westera JJ; Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands.
  • van de Rest O; Trajectum, Zwolle, The Netherlands.
  • van Hemert AM; 's Heeren Loo, Amersfoort, The Netherlands.
  • Giltay EJ; Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
J Appl Res Intellect Disabil ; 2022 Oct 12.
Article in English | MEDLINE | ID: covidwho-2240901
ABSTRACT

BACKGROUND:

Aggressive incidents are common in people with intellectual disabilities. Therefore, we aimed to assess whether supplementation of multivitamins, minerals, and omega-3 fatty acids (FA) reduces aggressive incidents.

METHODS:

We conducted a randomised, triple blind, placebo controlled, single crossover intervention trial. People with intellectual disabilities or borderline intellectual functioning, between 12 and 40 years of age, and showing aggressive behaviour were included. Participants received either a daily dose of dietary supplements, or placebo. Primary outcome was the number of aggressive incidents, measured using the Modified Overt Aggression Scale (MOAS).

RESULTS:

there were 113 participants (placebo, n = 56), of whom 24 (placebo, n = 10) participated in the crossover phase of the trial. All 137 trajectories were included in the analyses. There was no significant difference in mean number of aggressive incidents per day between those assigned to supplements and those who received placebo (rate ratio = 0.93 95% Confidence Interval [CI] = 0.59-1.45).

CONCLUSION:

In this pragmatic trial, we did not find significant differences in the outcomes between the supplement and placebo arms. The COVID-19 pandemic started midway through our trial, this may have affected the results.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Traditional medicine Language: English Year: 2022 Document Type: Article Affiliation country: Jar.13041

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Traditional medicine Language: English Year: 2022 Document Type: Article Affiliation country: Jar.13041