A young girl with fever and atypical rash

ABSTRACT

Kawasaki disease Scarlet fever Multisystem inflammatory syndrome in children (MIS-C) Hand, foot and mouth disease (coxsackievirus) For answer see page 02 For question see page 01 Answer C Multisystem inflammatory syndrome in children (MIS-C) was highly suspected because of the biological inflammatory syndrome and the Kawasaki-like dermatological presentation. Majority of published cases have positive serologic testing for SARS-CoV-2 (67%) and less commonly positive RT-PCR testing from nasopharyngeal testing (33%),2 suggesting that the pathogenesis of this syndrome involves post infection immune dysregulation rather than related to acute early infection.2 3 This affliction is life-threatening as it is usually associated with severe physiological impairment (hypotension, tachycardia) requiring admission in an intensive care unit in more than 50% of cases. Multi-System inflammatory syndrome in children (MIS-C) following SARS-CoV-2 infection review of clinical presentation, hypothetical pathogenesis, and proposed management.