Cefazolin-Associated INR Elevation: A Case Report.
J Pharm Pract
; : 8971900221132680, 2022 Oct 07.
Article
in English
| MEDLINE | ID: covidwho-2064562
ABSTRACT
PURPOSE:
To describe a case of significantly elevated international normalized ratio (INR) in a patient on apixaban receiving treatment with intravenous cefazolin in the setting of coronavirus disease 2019 (COVID-19) infection and malnutrition.SUMMARY:
A 74-year-old male patient on apixaban receiving cefazolin for osteomyelitis in the setting of COVID-19 and poor nutritional intake presented with internal jugular tunneled catheter site bleeding and an INR of greater than 22.5. Laboratory abnormalities and bleeding concerns were successfully managed with vitamin K and changing antimicrobial therapy from cefazolin to daptomycin. Follow-up labs one week later demonstrated a sustained improvement in coagulopathy.CONCLUSION:
INR prolongation believed to be secondary to cefazolin can be effectively managed with administration of vitamin K and conversion of antimicrobial therapy to an alternative agent.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Case report
/
Cohort study
/
Prognostic study
Language:
English
Journal:
J Pharm Pract
Journal subject:
Pharmacy
Year:
2022
Document Type:
Article
Affiliation country:
08971900221132680
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