Antibacterial and Phagocytic Properties of a Novel Silver-Interferon Complex
Anti-Infective Agents
; 20(4) (no pagination), 2022.
Article
in English
| EMBASE | ID: covidwho-2065292
ABSTRACT
Background:
Developing new antibacterial and antiviral drugs are considered a significant issue due to the emergence and spread of resistant strains of microorganisms. The COVID-19 pandemic has dramatically increased the need for new broad-spectrum anti-infective agents. Objective(s) This experimental study aimed to investigate the antibacterial and phagocytic properties of silver-interferon preparation. The combination of properties of complex drugs makes them promising for treating drug-resistant infections and bacterial complications of viral diseases. Method(s) The antibacterial effect of the silver-interferon platform was investigated by agar diffusion and serial dilution methods. The drug's effect on the functional activity of phagocytes was studied on human neutrophils in a Staphylococcus aureus uptake test. Result(s) Investigations have shown that the silver-interferon complex possesses a bactericidal mechanism of action against tested bacterial strains, including Streptococcus pneumonia, Salmonella enteritidis, Staphylococcus aureus, Escherichia coli. Streptococcus pneumonia was the most susceptible bacterial target for the tested complex, with a growth inhibition zone of 12+/-0.6 mm and a minimal bactericidal concentration of 0.08 mg/ml. A slight stimulating action of the drug in relation to the activity of phagocytes was revealed. Conclusion(s) Silver-interferon has proved as a prospective anti-infective drug with a wide range of activities. Copyright © 2022 Bentham Science Publishers.
antibacterial activity; immune-stimulation; interferon; nosocomial infections; phagocytosis; Silver; agar diffusion; article; bacterial growth; bacterial infection; bacterial strain; complication; controlled study; dilution; drug combination; Escherichia coli; growth inhibition; hospital infection; human; human cell; immunostimulation; minimum bactericidal concentration; neutrophil; nonhuman; phagocyte; Salmonella enterica serovar Enteritidis; Staphylococcus aureus; Streptococcus pneumonia; virus infection; zone of inhibition; antiinfective agent; endogenous compound
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Anti-Infective Agents
Year:
2022
Document Type:
Article
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