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Association of ACE2 Gene Variants with the Severity of COVID-19 Disease-A Prospective Observational Study.
Sienko, Jerzy; Marczak, Izabela; Kotowski, Maciej; Bogacz, Anna; Tejchman, Karol; Sienko, Magdalena; Kotfis, Katarzyna.
  • Sienko J; Department of General Surgery and Transplantology, Pomeranian Medical University, 70-111 Szczecin, Poland.
  • Marczak I; Department of Neurology, SUNY Downstate Medical Center, Brooklyn, NY 11023, USA.
  • Kotowski M; Department of General Surgery and Transplantology, Pomeranian Medical University, 70-111 Szczecin, Poland.
  • Bogacz A; Department of Stem Cells and Regenerative Medicine, Institute of Natural Fibers and Medicinal Plants, 62-064 Plewiska, Poland.
  • Tejchman K; Department of General Surgery and Transplantology, Pomeranian Medical University, 70-111 Szczecin, Poland.
  • Sienko M; Department of Pediatrics, Endocrinology, Diabetology, Metabolic Diseases, and Cardiology, Pomeranian Medical University, 71-252 Szczecin, Poland.
  • Kotfis K; Department of Anesthesiology, Intensive Therapy and Acute Intoxications, Pomeranian Medical University, 70-111 Szczecin, Poland.
Int J Environ Res Public Health ; 19(19)2022 Oct 02.
Article in English | MEDLINE | ID: covidwho-2066024
ABSTRACT
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 virus (SARS-CoV-2), has triggered an enormous scientific response. Many studies have focused on understanding the entry of the SARS-CoV-2 virus into the host cell. The angiotensin-converting enzyme-2 (ACE2) is recognized as the host receptor used by SARS-CoV-2 to enter its target cells. Recent studies suggest that ACE2 gene polymorphisms might be candidates for genetic susceptibility to SARS-CoV-2 infection. The aim of this study is to evaluate the influence of ACE2 polymorphisms on COVID-19 disease risk and severity. In our study, we confirmed that there is a statistically significant increased risk of a more severe disease course of SARS-CoV-2 infection associated with the need for hospitalization in intensive care for patients with specific polymorphisms of the ACE2 gene. The most significant correlation was found for variant ACE2 rs2285666 (AA allele, OR = 2.12, p = 0.0189) and ACE2 rs2074192 (TT allele, OR = 2.05, p = 0.0016), and for ACE2 rs4646174 (GG allele, OR = 1.93, p = 0.0016), ACE2 rs4646156 (TT allele OR = 1.71, p = 0.008) and ACE2 rs2158083 (TT allele OR = 1.84, p = 0.0025). In conclusion, our findings identify that certain ACE2 polymorphisms impact the severity of COVID-19 disease independently of other well-known risk factors.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Angiotensin-Converting Enzyme 2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Topics: Variants Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ijerph191912622

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Angiotensin-Converting Enzyme 2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Topics: Variants Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ijerph191912622