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Andrographis paniculata Dosage Forms and Advances in Nanoparticulate Delivery Systems: An Overview.
Raman, Subashini; Murugaiyah, Vikneswaran; Parumasivam, Thaigarajan.
  • Raman S; School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia.
  • Murugaiyah V; School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia.
  • Parumasivam T; Centre for Drug Research, Universiti Sains Malaysia, Penang 11800, Malaysia.
Molecules ; 27(19)2022 Sep 20.
Article in English | MEDLINE | ID: covidwho-2066270
ABSTRACT
Andrographis paniculata is a well-known Asian medicinal plant with a major phytoconstituent of diterpene lactones, such as andrographolide, 14-deoxyandrographolide, and neoandrographolide. A World Health Organization (WHO) monograph on selected medicinal plants showed that A. paniculata extracts and its major diterpene lactones have promising anti-inflammatory, antidiabetic, antimalarial, anticancer, antifungal, antibacterial, antioxidant, and hypoglycemic activities. However, these active phytochemicals have poor water solubility and bioavailability when delivered in a conventional dosage form. These biological barriers can be mitigated if the extract or isolated compound are delivered as nanoparticles. This review discusses existing studies and marketed products of A. paniculata in solid, liquid, semi-solid, and gaseous dosage forms, either as an extract or isolated pure compounds, as well as their deficits in reaching maximum bioavailability. The pharmaceutics and pharmacological activity of A. paniculata as a nano-delivery system are also discussed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Plants, Medicinal / Andrographis / Diterpenes / Antimalarials Topics: Traditional medicine Language: English Journal subject: Biology Year: 2022 Document Type: Article Affiliation country: Molecules27196164

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Plants, Medicinal / Andrographis / Diterpenes / Antimalarials Topics: Traditional medicine Language: English Journal subject: Biology Year: 2022 Document Type: Article Affiliation country: Molecules27196164