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Temperature Influences the Interaction between SARS-CoV-2 Spike from Omicron Subvariants and Human ACE2.
Gong, Shang Yu; Ding, Shilei; Benlarbi, Mehdi; Chen, Yaozong; Vézina, Dani; Marchitto, Lorie; Beaudoin-Bussières, Guillaume; Goyette, Guillaume; Bourassa, Catherine; Bo, Yuxia; Medjahed, Halima; Levade, Inès; Pazgier, Marzena; Côté, Marceline; Richard, Jonathan; Prévost, Jérémie; Finzi, Andrés.
  • Gong SY; Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.
  • Ding S; Department of Microbiology and Immunology, McGill University, Montreal, QC H3A 2B4, Canada.
  • Benlarbi M; Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.
  • Chen Y; Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.
  • Vézina D; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada.
  • Marchitto L; Infectious Disease Division, Department of Medicine of Uniformed Services, University of the Health Sciences, Bethesda, MD 20814-4712, USA.
  • Beaudoin-Bussières G; Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.
  • Goyette G; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada.
  • Bourassa C; Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.
  • Bo Y; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada.
  • Medjahed H; Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.
  • Levade I; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada.
  • Pazgier M; Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.
  • Côté M; Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.
  • Richard J; Department of Biochemistry, Microbiology and Immunology, Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
  • Prévost J; Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.
  • Finzi A; Laboratoire de Santé Publique du Québec, Institut National de Santé Publique du Québec, Sainte-Anne-de-Bellevue, QC H9X 3R5, Canada.
Viruses ; 14(10)2022 09 30.
Article in English | MEDLINE | ID: covidwho-2066552
ABSTRACT
SARS-CoV-2 continues to infect millions of people worldwide. The subvariants arising from the variant-of-concern (VOC) Omicron include BA.1, BA.1.1, BA.2, BA.2.12.1, BA.4, and BA.5. All possess multiple mutations in their Spike glycoprotein, notably in its immunogenic receptor-binding domain (RBD), and present enhanced viral transmission. The highly mutated Spike glycoproteins from these subvariants present different degrees of resistance to recognition and cross-neutralisation by plasma from previously infected and/or vaccinated individuals. We have recently shown that the temperature affects the interaction between the Spike and its receptor, the angiotensin converting enzyme 2 (ACE2). The affinity of RBD for ACE2 is significantly increased at lower temperatures. However, whether this is also observed with the Spike of Omicron and sub-lineages is not known. Here we show that, similar to other variants, Spikes from Omicron sub-lineages bind better the ACE2 receptor at lower temperatures. Whether this translates into enhanced transmission during the fall and winter seasons remains to be determined.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Angiotensin-Converting Enzyme 2 / COVID-19 Type of study: Randomized controlled trials Topics: Vaccines / Variants Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: V14102178

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Angiotensin-Converting Enzyme 2 / COVID-19 Type of study: Randomized controlled trials Topics: Vaccines / Variants Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: V14102178