Effect of magnesium on severity and mortality of COVID-19 patients: A systematic review
Journal of Acute Disease
; 11(4):120-126, 2022.
Article
in English
| EMBASE | ID: covidwho-2066823
ABSTRACT
Unbalanced magnesium levels in the body, like other minerals, are a factor that is important in the severity and mortality of COVID-19. This study was designed to investigate the relationship between serum magnesium levels and clinical outcomes in COVID-19 patients. In this systematic review, a comprehensive search was performed in PubMed, Scopus, and Web of Science databases until September 2021 by using the keywords COVID-19, severe acute respiratory syndrome coronavirus 2, coronavirus disease, SARS- COV-infection 2, SARS-COV-2, COVID 19, and magnesium. End-Note X7 software was used to manage the studies. Articles that evaluated effect of magnesium on COVID-19 were included in the analysis. After reviewing several articles,12 studies were finally included in the ultimate analysis. The studies show that hypomagnesemia and hypermagnesemia are both factors that increase mortality in patients with COVID-19, even in one study, hypomagnesemia is the cause of doubling thedeaths in COVID-19 patients. Some studies have also found a negative correlation between magnesium deficiency and infectionseverity, while some others have reported no correlation between magnesium level and disease severity. According to the important role of magnesium in the body and its involvement in many physiological reactions, as well as differences in physical and physiological conditions of COVID-19 patients, in addition to the need for studies with larger sample sizes, monitoring and maintaining normal serum magnesium levels during the disease seems necessary as a therapeutic target, especially in patients admitted to the intensive care unit.
C reactive protein; calcium; creatine kinase; creatinine; ferritin; magnesium; acute kidney failure; APACHE; artificial ventilation; calcium blood level; clinical outcome; comparative study; controlled study; coronavirus disease 2019; data analysis; disease severity; erythrocyte sedimentation rate; high risk patient; hospital admission; hospital patient; human; human tissue; hyperkalemia; hypermagnesemia; hypokalemia; hypomagnesemia; intensive care unit; kidney disease; leukocyte count; lobar pneumonia; lung injury; lymphocyte count; lymphocytopenia; magnesium blood level; magnesium deficiency; mortality rate; neutrophil count; Newcastle-Ottawa scale; oxygen therapy; physiological process; pregnant woman; quality assessment tool; respiratory failure; review; RNA blood level; Severe acute respiratory syndrome coronavirus 2; sex ratio; shock; software; systematic review; third trimester pregnancy
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Experimental Studies
/
Prognostic study
/
Reviews
/
Systematic review/Meta Analysis
Language:
English
Journal:
Journal of Acute Disease
Year:
2022
Document Type:
Article
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