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Seroprevalence of severe acute respiratory syndrome coronavirus 2 antibodies during the third wave of coronavirus disease in the Seoul metropolitan area of Korea.
Yoon, Kyuhyun; Kim, Jayeun; Peck, Kyong Ran; Kim, Hyun Soo; Lee, Hyukmin; Hwang, Yoo-Sung; Lee, Soon Young; Cho, Sung-Il; Lee, Hun Jae; Kim, Yeongyeong; Kim, Brian Byoungguk; Lee, June-Woo; Kim, Ah-Ra; Do, HyeonNam; Kim, Dong-Hyun.
  • Yoon K; Institute of Health and Environment, Seoul National University, Seoul, Korea.
  • Kim J; Korea Institute of Child Care and Education, Seoul, Korea.
  • Peck KR; Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • Kim HS; Department of Laboratory Medicine, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.
  • Lee H; Department of Laboratory Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • Hwang YS; Seegene Medical Foundation, Seoul, Korea.
  • Lee SY; Department of Preventive Medicine and Public Health, Ajou University School of Medicine, 164 World cup-ro, Yeongtong-gu, Suwon, Korea.
  • Cho SI; Graduate School of Public Health, Seoul National University, Seoul, Korea.
  • Lee HJ; Department of Social and Preventive Medicine, College of Medicine, Inha University, Incheon, Korea.
  • Kim Y; Department of Public Health Science, Graduate School of Public Health, Seoul National University, Seoul, Korea.
  • Kim BB; Division of Vaccine Clinical Research Center for Vaccine Research, National Institute of Infectious Diseases, National Institute of Health (NIH) Korea Disease Control and Prevention Agency (KDCA), CheongJu, Korea.
  • Lee JW; Division of Vaccine Clinical Research Center for Vaccine Research, National Institute of Infectious Diseases, National Institute of Health (NIH) Korea Disease Control and Prevention Agency (KDCA), CheongJu, Korea.
  • Kim AR; Division of Vaccine Clinical Research Center for Vaccine Research, National Institute of Infectious Diseases, National Institute of Health (NIH) Korea Disease Control and Prevention Agency (KDCA), CheongJu, Korea.
  • Do H; Division of Vaccine Clinical Research Center for Vaccine Research, National Institute of Infectious Diseases, National Institute of Health (NIH) Korea Disease Control and Prevention Agency (KDCA), CheongJu, Korea.
  • Kim DH; Hallym University College of Medicine, Chuncheon, Kangwon-do, Korea.
Epidemiol Health ; : e2022085, 2022 Sep 30.
Article in English | MEDLINE | ID: covidwho-2246598
ABSTRACT

Objectives:

After the third wave of coronavirus disease (COVID-19), by mid-February 2021, approximately 0.16% of the population was confirmed positive, which appeared to be one of the lowest rates worldwide at that time. However, asymptomatic transmission poses a challenge for COVID-19 surveillance. Therefore, a community-based serosurvey of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was conducted to understand the effectiveness of Korea's strong containment strategy.

Methods:

We collected 5,002 residual sera samples from January 30 to March 3, 2021 from 265 medical facilities in Seoul, 346 in Kyunggi-do' and 57 in Incheon. Among them, 60 samples from tertiary institutions were excluded. We defined the sub-regions according to the addresses of the medical facilities where the specimens were collected. Elecsys Anti-SARS-CoV-2 was used for the screening test, and positivity was confirmed using the SARS-CoV-2 sVNT Kit. Prevalence was estimated using sampling weight and the Wilson score interval for a binomial proportion with a 95% confidence interval.

Results:

Among the 4,942 specimens, 32 and 25 tested positive for COVID-19 in the screening and confirmatory tests, respectively. The overall crude prevalence of SARS-CoV-2 antibody was 0.51%. The population-adjusted overall prevalence was 0.55% in women and 0.38% in men. The region-specific estimation was 0.67% and 0.30% in Gyeonggi-do and Seoul, respectively. No positive cases were detected in Incheon.

Conclusion:

The proportion of undetected cases in South Korea remains low. Therefore, an infection control strategy with exhaustive tracing and widespread pre-emptive testing appears to be effective in containing the spread of the virus in the community.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Observational study / Prognostic study Language: English Journal: Epidemiol Health Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Observational study / Prognostic study Language: English Journal: Epidemiol Health Year: 2022 Document Type: Article