Oxygen Therapies and Clinical Outcomes for Patients Hospitalized With COVID-19: First Surge vs Second Surge
Journal of Clinical Outcomes Management
; 29(5):58-64, 2022.
Article
in English
| EMBASE | ID: covidwho-2067256
ABSTRACT
Objective:
To compare the utilization of oxygen therapies and clinical outcomes of patients admitted for COVID-19 during the second surge of the pandemic to that of patients admitted during the first surge. Design(s) Observational study using a registry database. Setting(s) Three hospitals (791 inpatient beds and 76 intensive care unit [ICU] beds) within the Beth Israel Lahey Health system in Massachusetts. Participant(s) We included 3183 patients with COVID-19 admitted to hospitals. Measurements Baseline data included demographics and comorbidities. Treatments included low-flow supplemental oxygen (2-6 L/min), high-flow oxygen via nasal cannula, and invasive mechanical ventilation. Outcomes included ICU admission, length of stay, ventilator days, and mortality. Result(s) A total of 3183 patients were included 1586 during the first surge and 1597 during the second surge. Compared to the first surge, patients admitted during the second surge had a similar rate of receiving low-flow supplemental oxygen (65.8% vs 64.1%, P= .3), a higher rate of receiving high-flow nasal cannula (15.4% vs 10.8%, P= .0001), and a lower ventilation rate (5.6% vs 9.7%, P< .0001). The outcomes during the second surge were better than those during the first surge lower ICU admission rate (8.1% vs 12.7%, P< .0001), shorter length of hospital stay (5 vs 6 days, P< .0001), fewer ventilator days (10 vs 16, P= .01), and lower mortality (8.3% vs 19.2%, P< .0001). Among ventilated patients, those who received high-flow nasal cannula had lower mortality. Conclusion(s) Compared to the first surge of the COVID-19 pandemic, patients admitted during the second surge had similar likelihood of receiving low-flow supplemental oxygen, were more likely to receive high-flow nasal cannula, were less likely to be ventilated, and had better outcomes. Copyright © 2022 Turner White Communications Inc.. All rights reserved.
high-flow nasal cannula; supplemental oxygen; ventilator; adult; article; artificial ventilation; breathing rate; clinical outcome; comorbidity; controlled study; coronavirus disease 2019; demographics; drug therapy; female; high flow nasal cannula therapy; hospital patient; hospitalization; human; intensive care unit; invasive ventilation; Israel; length of stay; major clinical study; male; Massachusetts; mortality; nasal cannula; observational study; outcome assessment; oxygen therapy; pandemic; ventilated patient; oxygen
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Prognostic study
Language:
English
Journal:
Journal of Clinical Outcomes Management
Year:
2022
Document Type:
Article
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