COVID 19 Effects on Patients with Compensated Cirrhosis
NeuroQuantology
; 20(10):7528-7533, 2022.
Article
in English
| EMBASE | ID: covidwho-2067316
ABSTRACT
Background:
The coronavirus disease 19 (COVID-19) is a highly transmittable and pathogenic viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in Wuhan, China and spread around the world. Genomic analysis revealed that SARS-CoV-2 is phylogenetically related to severe acute respiratory syndrome-like (SARS-like) bat viruses, therefore bats could be the possible primary reservoir.The intermediate source of origin and transfer to humans is not known, however, the rapid human to human transfer has been confirmed widely. There is no clinically approved antiviral drug or vaccine available to be used against COVID-19. However, few broad-spectrum antiviral drugs have been evaluated against COVID-19 in clinical trials, resulted in clinical recovery.The liver, the largest internal organ in the body, is essential in keeping the body functioning properly. It removes or neutralizes poisons from the blood, produces immune agents to control infection, and removes germs and bacteria from the blood. It makes proteins that regulate blood clotting and produces bile to help absorb fats and fat-soluble vitamins. Several studies have shown a significant risk of mortality in patients with cirrhosis and in liver transplantation recipients.2, 3, 4 The severity of presentation and risk of mortality is more in patients with decompensated cirrhosis.5,6 COVID-19 had lead to a significant decrease in number of liver transplant surgeries being performed, which would lead to an increased wait list mortality in these patients.
alanine aminotransferase; antivirus agent; creatinine; gamma glutamyltransferase; poison; vitamin; adult; angiogenesis; article; bile; blood clotting; body mass; cause of death; cholangiocyte; clinical evaluation; cohort analysis; coronavirus disease 2019; diabetes mellitus; dyspnea; extracellular matrix; fibrinolysis; fibroblast; fibrogenesis; fibrosis; hospitalization; human; hyperlipidemia; hypertension; immunosuppressive treatment; inflammation; ischemia; jaundice; liver cell; liver cirrhosis; liver function test; liver injury; liver transplantation; mortality; mortality risk; necrosis; obesity; pathogenesis; prothrombin time; retrospective study; risk factor; severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; stem cell; thrombosis; vasoconstriction
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Experimental Studies
Language:
English
Journal:
NeuroQuantology
Year:
2022
Document Type:
Article
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