Composition decipherment of Ficus pumila var. awkeotsang and its potential on COVID-19 symptom amelioration and in silico prediction of SARS-CoV-2 interference
Journal of Food and Drug Analysis
; 30(3):440-453, 2022.
Article
in English
| EMBASE | ID: covidwho-2067698
ABSTRACT
The jelly from achenes of Ficus pumila var. awkeotsang (FPAA) is a famous beverage ingredient in Taiwan. In this work, ficumarin (1), a new compound was obtained from its twigs (FPAT) and elucidated with comprehensive spectroscopic data. The biosynthetic origin was proposed from the p-coumaroyl-CoA pathway. Alloxanthoxyletin, betulinic acid, and catechin were identified as the major and active constituents responsible for relieving neutrophilic inflammation by FPAT. Among them, the most potent alloxanthoxyletin was found to interact with PRO350 and GLU377 of human INOSOX. Further, Nrf2 activating capacity of the FPAT fraction and its coumarins was confirmed. With the analysis of LC-MS/MS data and feature-based molecular networking, coumarins were found as the dominant and responsible components. Notably, alloxanthoxyletin increased Nrf2 expression by up to 816.8 +/- 58% due to the interacting with the VAL561, THR560 and VAL420 residues of 5FNQ protein. COVID-19 Docking Server simulation indicated that pyranocoumarins would promisingly interfere with the life cycle of SARS-CoV-2. FPAT was proven to exert. Copyright © 2022 Taiwan Food and Drug Administration.
article; computer model; controlled study; coronavirus disease 2019; Ficus; gene expression; human; life cycle; liquid chromatography-mass spectrometry; neutrophilic inflammation; nonhuman; prediction; protein expression; Severe acute respiratory syndrome coronavirus 2; simulation; twig; betulic acid; catechin; coumarin derivative; endogenous compound; pyranocoumarin derivative; transcription factor Nrf2; unclassified drug
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Prognostic study
Language:
English
Journal:
Journal of Food and Drug Analysis
Year:
2022
Document Type:
Article
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