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New In Situ-Generated Polymer-Iodine Complexes with Broad-Spectrum Antimicrobial Activity.
López-Álvarez, Marina; Ulmer, Herb; Klay, Nico; van Dijl, Jan Maarten.
  • López-Álvarez M; Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Ulmer H; X-Infex B.V., Bussum, The Netherlands.
  • Klay N; X-Infex B.V., Bussum, The Netherlands.
  • van Dijl JM; Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Microbiol Spectr ; 10(5): e0055022, 2022 Oct 26.
Article in English | MEDLINE | ID: covidwho-2068501
ABSTRACT
Iodine-containing systems show broad antiseptic properties that can be an invaluable tool in controlling infections in humans and animals. Here, we describe the first proof-of-concept studies on biocidal active polyamide- and polyurethane-iodine complexes that are produced in situ directly during the fabrication and/or polymerization process at laboratory and commercially relevant scales. These polymer-iodine materials are active against a broad range of microorganisms, including bacteria and fungi. It is suggested that the ease of manufacture and subsequent commercialization make said systems especially suited for applications as base materials for medical devices to reduce infection risks and control the spread of pathogens. IMPORTANCE Infectious diseases are of mounting medical and public concern. A major contributor to this trend is the proliferation of medical implants, which are inherently vulnerable to microbial contamination and the subsequent onset of hospital-acquired infections. Moreover, implant-associated infections in humans are often difficult to diagnose and treat and are associated with substantial health care costs. Here, we present the development of biocidal active polyamide- and polyurethane-iodine complexes that are generated in situ during fabrication. We show that the excellent antiseptic properties of water-soluble povidone-iodine can be similarly realized in water-insoluble engineering plastics, specifically polyamide- and polyurethane-iodine. These complexes have inherent biocidal activity against major pathogenic bacteria and fungi.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Iodine / Anti-Infective Agents, Local Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Microbiol Spectr Year: 2022 Document Type: Article Affiliation country: Spectrum.00550-22

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Iodine / Anti-Infective Agents, Local Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Microbiol Spectr Year: 2022 Document Type: Article Affiliation country: Spectrum.00550-22