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The role of SARS-CoV-2 accessory proteins in immune evasion.
Zandi, Milad; Shafaati, Maryam; Kalantar-Neyestanaki, Davood; Pourghadamyari, Hossein; Fani, Mona; Soltani, Saber; Kaleji, Hassan; Abbasi, Samaneh.
  • Zandi M; Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: mzandi@razi.tums.ac.ir.
  • Shafaati M; Department of Microbiology, Faculty Science, Jahrom Branch, Islamic Azad University, Jahrom, Iran; Occupational Sleep Research Center, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Kalantar-Neyestanaki D; Medical Mycology and Bacteriology Research Center, Kerman University of Medical Sciences, Kerman, Iran; Department of Medical Microbiology (Bacteriology & Virology), Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
  • Pourghadamyari H; Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran; Department of Clinical Biochemistry, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
  • Fani M; Department of Pathobiology & Laboratory Sciences, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
  • Soltani S; Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
  • Kaleji H; Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
  • Abbasi S; Department of Microbiology, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran. Electronic address: s.abbasi@abadanums.ac.ir.
Biomed Pharmacother ; 156: 113889, 2022 Dec.
Article in English | MEDLINE | ID: covidwho-2068730
ABSTRACT
Many questions on the SARS-CoV-2 pathogenesis remain to answer. The SARS-CoV-2 genome encodes some accessory proteins that are essential for infection. Notably, accessory proteins of SARS-CoV-2 play significant roles in affecting immune escape and viral pathogenesis. Therefore SARS-CoV-2 accessory proteins could be considered putative drug targets. IFN-I and IFN-III responses are the primary mechanisms of innate antiviral immunity in infection clearance. Previous research has shown that SARS-CoV-2 suppresses IFN-ß by infecting host cells via ORF3a, ORF3b, ORF6, ORF7a, ORF7b, ORF8, and ORF9b. Furthermore, ORF3a, ORF7a, and ORF7b have a role in blocking IFNα signaling, and ORF8 represses IFNß signaling. The ORF3a, ORF7a, and ORF7b disrupt the STAT1/2 phosphorylation. ORF3a, ORF6, ORF7a, and ORF7b could prevent the ISRE promoter activity. The main SARS-CoV-2 accessory proteins involved in immune evasion are discussed here for comprehensive learning on viral entry, replication, and transmission in vaccines and antiviral development.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: Biomed Pharmacother Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: Biomed Pharmacother Year: 2022 Document Type: Article