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Impact of glycemia and insulin treatment in fatal outcome of severe fever with thrombocytopenia syndrome.
Ge, Honghan; Zhao, Jing; Zhang, Shuai; Xu, Yanli; Liu, Yuanni; Peng, Xuefang; Wang, Gang; Gong, Xiaoyi; Zhang, Ligang; Li, Shuang; Li, Hao; Zhang, Xiao-Ai; Cui, Ning; Yuan, Chun; Lin, Ling; Liu, Wei.
  • Ge H; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, P. R. China.
  • Zhao J; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, P. R. China.
  • Zhang S; Department of Clinical Laboratory, Yantai Qishan Hospital, Yantai, Shandong Province, China.
  • Xu Y; Department of Infectious Diseases, Yantai Qishan Hospital, Yantai, Shandong Province, China.
  • Liu Y; Department of Infectious Diseases, Yantai Qishan Hospital, Yantai, Shandong Province, China.
  • Peng X; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, P. R. China.
  • Wang G; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, P. R. China.
  • Gong X; Department of Infectious Diseases, Yantai Qishan Hospital, Yantai, Shandong Province, China.
  • Zhang L; Department of Infectious Diseases, Yantai Qishan Hospital, Yantai, Shandong Province, China.
  • Li S; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, P. R. China.
  • Li H; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, P. R. China.
  • Zhang XA; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, P. R. China.
  • Cui N; The 990th Hospital of Joint Logistic Support Force of Chinese People's Liberation Army, Xinyang, China.
  • Yuan C; The 990th Hospital of Joint Logistic Support Force of Chinese People's Liberation Army, Xinyang, China.
  • Lin L; Department of Infectious Diseases, Yantai Qishan Hospital, Yantai, Shandong Province, China. Electronic address: linling4012@163.com.
  • Liu W; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, P. R. China; Department of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, China; Beijing Key Laboratory of Vector Borne and Natural Focus Infectio
Int J Infect Dis ; 119: 24-31, 2022 Jun.
Article in English | MEDLINE | ID: covidwho-2069113
ABSTRACT

BACKGROUND:

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease with a high fatality rate. How the glucose level might affect the clinical outcome remains obscure.

METHODS:

A multicenter study was performed in 2 hospitals from 2011 to 2021. Patients with SFTS and acute hyperglycemia (admission fasting plasma glucose [FPG] ≥7 mmol/L), postadmission hyperglycemia (admission FPG <7 mmol/L but FPG ≥7 mmol/L after admission), and euglycemia (FPG <7 mmol/L throughout hospitalization) were compared for their clinical progress and outcomes.

RESULTS:

A total of 3225 patients were included in this study, 37.9% of whom developed acute hyperglycemia and 7.6% postadmission hyperglycemia. The presence of acute hyperglycemia, with or without known diabetes, was associated with increased risk of death (odds ratio [OR] 1.63; 95% confidence interval [CI] 1.29-2.05) compared with euglycemia. This effect, however, was only determined in female patients (OR 2.15; 95% CI 1.54-2.93). Insulin treatment of patients with SFTS and acute hyperglycemia without previous diabetes was associated with significantly increased mortality (OR 1.58; 95% CI 1.16-2.16).

CONCLUSION:

Acute hyperglycemia can act as a strong predictor of SFTS-related death in female patients. Insulin treatment of hyperglycemia in patients with SFTS without pre-existing diabetes has adverse effects.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetes Mellitus / Insulins / Severe Fever with Thrombocytopenia Syndrome / Hyperglycemia Type of study: Experimental Studies / Prognostic study Topics: Long Covid Limits: Female / Humans Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetes Mellitus / Insulins / Severe Fever with Thrombocytopenia Syndrome / Hyperglycemia Type of study: Experimental Studies / Prognostic study Topics: Long Covid Limits: Female / Humans Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article