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Effect of fluvoxamine on outcomes of nonhospitalized patients with COVID-19: A systematic review and meta-analysis.
Lu, Li-Chin; Chao, Chien-Ming; Chang, Shen-Peng; Lan, Shao-Huan; Lai, Chih-Cheng.
  • Lu LC; School of Management, Putian University, Putian 351100, China.
  • Chao CM; Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan.
  • Chang SP; Yijia Pharmacy, Tainan 70846, Taiwan.
  • Lan SH; School of Pharmaceutical Sciences and Medical Technology, Putian University, Putian 351100, China.
  • Lai CC; Division of Hospital Medicine, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan. Electronic address: dtmed141@gmail.com.
J Infect Public Health ; 15(11): 1259-1264, 2022 Oct 13.
Article in English | MEDLINE | ID: covidwho-2069352
ABSTRACT

OBJECTIVES:

This meta-analysis investigated the use of fluvoxamine for the treatment of nonhospitalized patients with COVID-19.

METHODS:

PubMed, Web of Science, Ovid medline, Embase, Scopus, Cochrane Library databases, and ClinicalTrials.gov were searched for studies published before June 25, 2022. Only clinical studies that compared the efficacy and safety of fluvoxamine with other alternatives or placebos in the treatment of nonhospitalized patients with COVID-19 were included.

RESULTS:

Four studies with 1814 patients, of whom 912 received fluvoxamine, were included in this study. Compared with the control group receiving placebo or no therapy, the study group receiving fluvoxamine demonstrated a lower risk of hospitalization and emergency department (ED) visits (odds ratio [OR], 0.59; 95 % CI, 0.44-0.79; I2 = 26 %). In addition, the rate of hospitalization remained significantly lower in patients who received fluvoxamine than in the control group (OR, 0.69; 95 % CI, 0.51-0.94; I2 = 36 %). Although the study group demonstrated a lower risk of requirement of mechanical ventilation and intensive care unit admission, and mortality than the control group, these differences were nonsignificant. Finally, fluvoxamine use was associated with a similar risk of adverse events as that observed in the control group.

CONCLUSION:

Fluvoxamine can be safely used in nonhospitalized patients with COVID-19 and can reduce the hospitalization rate or ED visits in these patients.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Language: English Journal: J Infect Public Health Journal subject: Communicable Diseases / Public Health Year: 2022 Document Type: Article Affiliation country: J.jiph.2022.10.010

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Language: English Journal: J Infect Public Health Journal subject: Communicable Diseases / Public Health Year: 2022 Document Type: Article Affiliation country: J.jiph.2022.10.010