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Novel coronavirus mutations: Vaccine development and challenges.
Luo, Wan-Rong; Wu, Xiao-Min; Wang, Wei; Yu, Jun-Ling; Chen, Qing-Qing; Zhou, Xue; Huang, Xin'er; Pan, Hai-Feng; Liu, Zhi-Rong; Gao, Yong; He, Jun.
  • Luo WR; Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, Anhui, China.
  • Wu XM; Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, Anhui, China.
  • Wang W; The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), 17 Lujiang Road, Hefei, Anhui, China.
  • Yu JL; Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, Anhui, China.
  • Chen QQ; Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, Anhui, China.
  • Zhou X; Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, Anhui, China.
  • Huang X; Department of Health Inspection and Quarantine, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China.
  • Pan HF; Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China.
  • Liu ZR; Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, Anhui, China; Department of Microbiology Laboratory, Public Health Research Institute of Anhui Province, 12560, Fanhua Avenue, Hefei, Anhui, China. Electronic address: lzr@ahcdc.com.cn.
  • Gao Y; The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), 17 Lujiang Road, Hefei, Anhui, China. Electronic address: ygao387@ustc.edu.cn.
  • He J; Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, Anhui, China; Department of Microbiology Laboratory, Public Health Research Institute of Anhui Province, 12560, Fanhua Avenue, Hefei, Anhui, China; Department of Health Inspection and Quarantine, School of
Microb Pathog ; 173(Pt A): 105828, 2022 Dec.
Article in English | MEDLINE | ID: covidwho-2069488
ABSTRACT
The ongoing global pandemic of novel coronavirus pneumonia (COVID-19) caused by the SARS-CoV-2 has a significant impact on global health and economy system. In this context, there have been some landmark advances in vaccine development. Over 100 new coronavirus vaccine candidates have been approved for clinical trials, with ten WHO-approved vaccines including four inactivated virus vaccines, two mRNA vaccines, three recombinant viral vectored vaccines and one protein subunit vaccine on the "Emergency Use Listing". Although the SARS-CoV-2 has an internal proofreading mechanism, there have been a number of mutations emerged in the pandemic affecting its transmissibility, pathogenicity and immunogenicity. Of these, mutations in the spike (S) protein and the resultant mutant variants have posed new challenges for vaccine development and application. In this review article, we present an overview of vaccine development, the prevalence of new coronavirus variants and their impact on protective efficacy of existing vaccines and possible immunization strategies coping with the viral mutation and diversity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Vaccines / COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines / Variants Limits: Humans Language: English Journal: Microb Pathog Journal subject: Communicable Diseases / Microbiology Year: 2022 Document Type: Article Affiliation country: J.micpath.2022.105828

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Vaccines / COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines / Variants Limits: Humans Language: English Journal: Microb Pathog Journal subject: Communicable Diseases / Microbiology Year: 2022 Document Type: Article Affiliation country: J.micpath.2022.105828