Impact of prior bariatric surgery on risk and severity of COVID-19 infection: A meta-analysis of observational studies.
Obes Res Clin Pract
; 16(6): 439-446, 2022.
Article
in English
| MEDLINE | ID: covidwho-2069535
ABSTRACT
BACKGROUND:
The association of prior bariatric surgery (BS) with infection rate and prognosis of coronavirus disease 2019 (COVID-19) remains unclear. We conducted a meta-analysis of observational studies to address this issue.METHODS:
We searched databases including MEDLINE, Embase, and CENTRAL from inception to May, 2022. The primary outcome was risk of mortality, while secondary outcomes included risk of hospital/intensive care unit (ICU) admission, mechanical ventilation, acute kidney injury (AKI), and infection rate.RESULTS:
Eleven studies involving 151,475 patients were analyzed. Meta-analysis showed lower risks of mortality [odd ratio (OR)= 0.42, 95% CI 0.27-0.65, p < 0.001, I2 = 67%; nine studies; 151,113 patients, certainty of evidence (COE)moderate], hospital admission (OR=0.56, 95% CI 0.36-0.85, p = 0.007, I2 =74.6%; seven studies; 17,810 patients; COElow), ICU admission (OR=0.5, 95% CI 0.37-0.67, p < 0.001, I2 =0%; six studies; 17,496 patients, COEmoderate), mechanical ventilation (OR=0.52, 95% CI 0.37-0.72, p < 0.001, I2 =57.1%; seven studies; 137,992 patients, COEmoderate) in patients with prior BS (BS group) than those with obesity without surgical treatment (non-BS group). There was no difference in risk of AKI (OR=0.74, 95% CI 0.41-1.32, p = 0.304, I2 =83.6%; four studies; 129,562 patients, COE very low) and infection rate (OR=1.05, 95% CI 0.89-1.22, p = 0.572, I2 =0%; four studies; 12,633 patients, COElow) between the two groups. Subgroup analysis from matched cohort studies demonstrated associations of prior BS with lower risks of mortality, ICU admission, mechanical ventilation, and AKI.CONCLUSION:
Our results showed a correlation between prior BS and less severe COVID-19, which warrants further investigations to verify.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Bariatric Surgery
/
Acute Kidney Injury
/
COVID-19
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
/
Reviews
Limits:
Humans
Language:
English
Journal:
Obes Res Clin Pract
Year:
2022
Document Type:
Article
Affiliation country:
J.orcp.2022.10.005
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