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Optic neuritis in lung adenocarcinoma: A challenging diagnosis.
Goudsmit, Anouk; Brandao, Mariana; Oullai, Ali; Engelman, Dan; Ghorra, Nathalie; Daif, Tarik; Buelens, Tom; Meert, Anne-Pascale.
  • Goudsmit A; Medical Oncology Department, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium. Electronic address: Anouk.goudsmit@hotmail.com.
  • Brandao M; Medical Oncology Department, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium.
  • Oullai A; Internal Medicine Department, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels Belgium.
  • Engelman D; Internal Medicine Department, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels Belgium.
  • Ghorra N; LHUB-ULB, Université Libre de Bruxelles (ULB), Brussels, Belgium.
  • Daif T; Ophthalmology Department, CHU Saint Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium.
  • Buelens T; Ophthalmology Department, CHU Saint Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium.
  • Meert AP; Internal Medicine Department, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels Belgium.
Respir Med Res ; 82: 100966, 2022 Nov.
Article in English | MEDLINE | ID: covidwho-2069628
ABSTRACT
Optic neuritis with CRMP-5 IgG is a paraneoplastic inflammation of the optic nerve associated with lung cancer, mostly small-cell lung cancer. We present the case of a patient with lung adenocarcinoma who developed progressive bilateral visual loss a few months after immune-chemotherapy with pembrolizumab and after Covid-19 vaccination. Positive CRMP-5 IgG were detected in blood sample and complete work-up - including brain MRI - did not show any progression. High dose systemic corticoids were administered with transient improving, followed by intravenous immunoglobulins, methotrexate and rituximab but despite negativization of CRMP-5 IgG, the patient had a progressive visual loss.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Optic Neuritis / Adenocarcinoma of Lung / COVID-19 / Lung Neoplasms Type of study: Case report / Diagnostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Respir Med Res Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Optic Neuritis / Adenocarcinoma of Lung / COVID-19 / Lung Neoplasms Type of study: Case report / Diagnostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Respir Med Res Year: 2022 Document Type: Article