Your browser doesn't support javascript.
Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques.
Li, Pingchao; Wang, Qian; He, Yizi; Yang, Chenchen; Zhang, Zhengyuan; Liu, Zijian; Liu, Bo; Yin, Li; Cui, Yilan; Hu, Peiyu; Liu, Yichu; Zheng, Pingqian; Wang, Wei; Qu, Linbing; Sun, Caijun; Guan, Suhua; Feng, Liqiang; Chen, Ling.
  • Li P; State Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, China.
  • Wang Q; State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • He Y; State Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, China.
  • Yang C; University of Chinese Academy of Sciences, Beijing, China.
  • Zhang Z; Guangzhou nBiomed Ltd., Guangzhou, China.
  • Liu Z; State Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, China.
  • Liu B; University of Chinese Academy of Sciences, Beijing, China.
  • Yin L; State Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, China.
  • Cui Y; University of Chinese Academy of Sciences, Beijing, China.
  • Hu P; Guangzhou nBiomed Ltd., Guangzhou, China.
  • Liu Y; State Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, China.
  • Zheng P; University of Chinese Academy of Sciences, Beijing, China.
  • Wang W; State Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, China.
  • Qu L; University of Chinese Academy of Sciences, Beijing, China.
  • Sun C; Guangzhou Laboratory & Bioland Laboratory, Guangzhou, China.
  • Guan S; State Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, China.
  • Feng L; Guangzhou Laboratory & Bioland Laboratory, Guangzhou, China.
  • Chen L; Guangzhou Laboratory & Bioland Laboratory, Guangzhou, China.
Emerg Microbes Infect ; : 1-51, 2022 Oct 14.
Article in English | MEDLINE | ID: covidwho-2268776
ABSTRACT
Prolonged infection and possible evolution of SARS-CoV-2 in patients living with uncontrolled HIV-1 infection highlight the importance of an effective vaccination regimen, yet the immunogenicity of COVID-19 vaccines and predictive immune biomarkers have not been well investigated. Herein, we report that the magnitude and persistence of antibody and cell-mediated immunity (CMI) elicited by an Ad5-vectored COVID-19 vaccine are impaired in SIV-infected macaques with high viral loads (> 105 genome copies per ml plasma, SIVhi) but not in macaques with low viral loads (< 105, SIVlow). After a second vaccination, the immune responses are robustly enhanced in all uninfected and SIVlow macaques. These responses also show a moderate increase in 70% SIVhi macaques but decline sharply soon after. Further analysis reveals that decreased antibody and CMI responses are associated with reduced circulating follicular helper T cell (TFH) counts and aberrant CD4/CD8 ratios, respectively, indicating that dysregulation of CD4+ T cells by SIV infection impairs the COVID-19 vaccine-induced immunity. Ad5-vectored COVID-19 vaccine shows no impact on SIV loads or SIV-specific CMI responses. Our study underscores the necessity of frequent booster vaccinations in HIV-infected patients and provides indicative biomarkers for predicting vaccination effectiveness in these patients.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines Language: English Journal: Emerg Microbes Infect Year: 2022 Document Type: Article Affiliation country: 22221751.2022.2136538

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines Language: English Journal: Emerg Microbes Infect Year: 2022 Document Type: Article Affiliation country: 22221751.2022.2136538