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Potential Therapeutic Approach of Melatonin against Omicron and Some Other Variants of SARS-CoV-2.
Begum, Rahima; Mamun-Or-Rashid, A N M; Lucy, Tanzima Tarannum; Pramanik, Md Kamruzzaman; Sil, Bijon Kumar; Mukerjee, Nobendu; Tagde, Priti; Yagi, Masayuki; Yonei, Yoshikazu.
  • Begum R; Department of Microbiology, Gono Bishwabidyalay, Dhaka 1344, Bangladesh.
  • Mamun-Or-Rashid ANM; Anti-Aging Medical Research Center, Graduate School of Life and Medical Sciences, Doshisha University 1-3 TataraMiyakodani, Kyoto 610-0394, Japan.
  • Lucy TT; Glycative Stress Research Center, Graduate School of Life and Medical Sciences, Doshisha University 1-3 Tatara Miyakodani, Kyoto 610-0394, Japan.
  • Pramanik MK; Department of Environmental & Occupational Health, School of Public Health, University of Pittsburgh, 130 De Soto Str., Pittsburgh, PA 15231, USA.
  • Sil BK; Anti-Aging Medical Research Center, Graduate School of Life and Medical Sciences, Doshisha University 1-3 TataraMiyakodani, Kyoto 610-0394, Japan.
  • Mukerjee N; Glycative Stress Research Center, Graduate School of Life and Medical Sciences, Doshisha University 1-3 Tatara Miyakodani, Kyoto 610-0394, Japan.
  • Tagde P; Microbiology and Industrial Irradiation Division, Institute of Food and Radiation Biology, Atomic Energy Research Establishment, Savar 1349, Bangladesh.
  • Yagi M; Department of Microbiology, Gono Bishwabidyalay, Dhaka 1344, Bangladesh.
  • Yonei Y; Department of Microbiology, Ramakrishna Mission Vivekananda Centenary College, Kolkata 700118, India.
Molecules ; 27(20)2022 Oct 16.
Article in English | MEDLINE | ID: covidwho-2071652
ABSTRACT
The Omicron variant (B.529) of COVID-19 caused disease outbreaks worldwide because of its contagious and diverse mutations. To reduce these outbreaks, therapeutic drugs and adjuvant vaccines have been applied for the treatment of the disease. However, these drugs have not shown high efficacy in reducing COVID-19 severity, and even antiviral drugs have not shown to be effective. Researchers thus continue to search for an effective adjuvant therapy with a combination of drugs or vaccines to treat COVID-19 disease. We were motivated to consider melatonin as a defensive agent against SARS-CoV-2 because of its various unique properties. Over 200 scientific publications have shown the significant effects of melatonin in treating diseases, with strong antioxidant, anti-inflammatory, and immunomodulatory effects. Melatonin has a high safety profile, but it needs further clinical trials and experiments for use as a therapeutic agent against the Omicron variant of COVID-19. It might immediately be able to prevent the development of severe symptoms caused by the coronavirus and can reduce the severity of the infection by improving immunity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Drug Treatment / Melatonin Type of study: Prognostic study Topics: Vaccines / Variants Limits: Humans Language: English Journal subject: Biology Year: 2022 Document Type: Article Affiliation country: Molecules27206934

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Drug Treatment / Melatonin Type of study: Prognostic study Topics: Vaccines / Variants Limits: Humans Language: English Journal subject: Biology Year: 2022 Document Type: Article Affiliation country: Molecules27206934