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COVID-19 in Infants Less than 3 Months: Severe or Not Severe Disease?
Dona', Daniele; Montagnani, Carlotta; Di Chiara, Costanza; Venturini, Elisabetta; Galli, Luisa; Lo Vecchio, Andrea; Denina, Marco; Olivini, Nicole; Bruzzese, Eugenia; Campana, Andrea; Giacchero, Roberta; Salvini, Filippo; Meini, Antonella; Ponzoni, Matteo; Trapani, Sandra; Rossi, Elena; Lombardi, Mary Haywood; Badolato, Raffaele; Pierri, Luca; Pruccoli, Giulia; Rossin, Sara; Colomba, Claudia; Cazzato, Salvatore; Pacati, Ilaria; Nicolini, Giangiacomo; Pierantoni, Luca; Bianchini, Sonia; Krzysztofiak, Andrzej; Garazzino, Silvia; Giaquinto, Carlo; Castelli Gattinara, Guido.
  • Dona' D; Division of Pediatric Infectious Diseases, Department for Women's and Children's Health, University of Padua, 35128 Padua, Italy.
  • Montagnani C; Pediatric Infectious Diseases Division, Anna Meyer Children's University Hospital, 50139 Florence, Italy.
  • Di Chiara C; Division of Pediatric Infectious Diseases, Department for Women's and Children's Health, University of Padua, 35128 Padua, Italy.
  • Venturini E; Pediatric Infectious Diseases Division, Anna Meyer Children's University Hospital, 50139 Florence, Italy.
  • Galli L; Pediatric Infectious Diseases Division, Anna Meyer Children's University Hospital, 50139 Florence, Italy.
  • Lo Vecchio A; Department of Health Sciences, University of Florence, 50121 Florence, Italy.
  • Denina M; Department of Translational Medical Sciences, University of Naples Federico II, 80138 Naples, Italy.
  • Olivini N; Department of Pediatrics, Infectious Diseases Unit, University of Turin, Regina Margherita Children's Hospital, 10126 Turin, Italy.
  • Bruzzese E; Ospedale Pediatrico Bambino Gesù, UOC Pediatria Multispecialistica, Fiumicino, 00050 Rome, Italy.
  • Campana A; Department of Translational Medical Sciences, University of Naples Federico II, 80138 Naples, Italy.
  • Giacchero R; Ospedale Pediatrico Bambino Gesù, UOC Pediatria Multispecialistica, Fiumicino, 00050 Rome, Italy.
  • Salvini F; UOC Pediatria-ASST Lodi, 26900 Lodi, Italy.
  • Meini A; Department of Pediatrics, Niguarda Hospital, 20162 Milan, Italy.
  • Ponzoni M; Department of Experimental and Clinical Sciences, Pediatric Clinic, University of Brescia, 25121 Brescia, Italy.
  • Trapani S; Pediatric and Congenital Cardiac Surgery Unit, Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, 35128 Padova, Italy.
  • Rossi E; Pediatric Infectious Diseases Division, Anna Meyer Children's University Hospital, 50139 Florence, Italy.
  • Lombardi MH; Department of Health Sciences, University of Florence, 50121 Florence, Italy.
  • Badolato R; UOC Pediatria-ASST Lodi, 26900 Lodi, Italy.
  • Pierri L; Ospedale Pediatrico Bambino Gesù, UOC Pediatria Multispecialistica, Fiumicino, 00050 Rome, Italy.
  • Pruccoli G; Department of Experimental and Clinical Sciences, Pediatric Clinic, University of Brescia, 25121 Brescia, Italy.
  • Rossin S; Department of Translational Medical Sciences, University of Naples Federico II, 80138 Naples, Italy.
  • Colomba C; Department of Pediatrics, Infectious Diseases Unit, University of Turin, Regina Margherita Children's Hospital, 10126 Turin, Italy.
  • Cazzato S; Pediatric Emergency Department, Department for Woman and Child Health, University of Padua, 35128 Padua, Italy.
  • Pacati I; Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Infectious Diseases Unit, University of Palermo, 90133 Palermo, Italy.
  • Nicolini G; Paediatric Unit, Department of Mother and Child Health, Salesi Children's Hospital, 60123 Ancona, Italy.
  • Pierantoni L; Paediatric Unit, Ospedale Bolognini ASST Bergamo Est, 24068 Seriate, Italy.
  • Bianchini S; Pediatric Unit, San Martino Hospital, 32100 Belluno, Italy.
  • Krzysztofiak A; Medical and Surgical Science Department, S Orsola University Hospital, 40138 Bologna, Italy.
  • Garazzino S; Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, 06132 Perugia, Italy.
  • Giaquinto C; Pediatric and Infectious Diseases Unit, Academic Department, Bambino Gesù Pediatric Hospital, 00146 Rome, Italy.
  • Castelli Gattinara G; Department of Pediatrics, Infectious Diseases Unit, University of Turin, Regina Margherita Children's Hospital, 10126 Turin, Italy.
  • On Behalf Of The Italian Sitip-Sip Pediatric Sars-CoV-Infection Study Group; Division of Pediatric Infectious Diseases, Department for Women's and Children's Health, University of Padua, 35128 Padua, Italy.
Viruses ; 14(10)2022 10 14.
Article in English | MEDLINE | ID: covidwho-2071836
ABSTRACT
Compared to adults, severe or fatal COVID-19 disease is much less common in children. However, a higher risk for progression has been reported in infants. Different pediatric COVID-19 severity scores are reported in the literature.

METHODS:

Subjects under 90 days of age admitted to 35 Italian institutions for COVID-19 were included. The severity of COVID-19 was scored as mild/moderate or severe/critical following the classification reported in the literature by Venturini, Dong, Kanburoglu, and Gale. To assess the diagnostic accuracy of each classification system, we stratified all enrolled patients developing a posteriori severity score based on clinical presentation and outcomes and then compared all different scores analyzed.

RESULTS:

We included 216 infants below 90 days of age. The most common symptom was fever, followed by coryza, poor feeding, cough, and gastrointestinal manifestations. According to Venturini, Dong, Kanburoglu, and Gale's severity scores, 18%, 6%, 4.2%, and 29.6% of infants presented with severe/critical disease, respectively. A correlation analysis between these four scores and the a posteriori severity score assigned to all enrolled subjects was performed, and a crescent strength of correlation from Gale (R = 0.355, p < 0.001) to Venturini (R = 0.425, p < 0.001), Dong (R = 0.734, p < 0.001), and Kanburoglu (R = 0.859, p < 0.001) was observed.

CONCLUSIONS:

The percentage of infants with severe COVID-19 varies widely according to the score systems. A unique clinical score should be designed for neonates and infants with COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Prognostic study Limits: Adult / Child / Humans / Infant / Infant, Newborn Language: English Year: 2022 Document Type: Article Affiliation country: V14102256

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Prognostic study Limits: Adult / Child / Humans / Infant / Infant, Newborn Language: English Year: 2022 Document Type: Article Affiliation country: V14102256