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The Treatment of COVID-19 With Monoclonal Antibody Therapy: Patient-Reported Outcomes.
Lamour, Daniella; Vafadari, Nika; Clayton, Lisa M; Solano, Joshua J; Hughes, Patrick G; Shih, Richard D; Alter, Scott M.
  • Lamour D; Department of Emergency Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA.
  • Vafadari N; Department of Emergency Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA.
  • Clayton LM; Department of Emergency Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA.
  • Solano JJ; Department of Emergency Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA.
  • Hughes PG; Department of Emergency Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA.
  • Shih RD; Department of Emergency Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA.
  • Alter SM; Department of Emergency Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA.
Cureus ; 14(9): e29247, 2022 Sep.
Article in English | MEDLINE | ID: covidwho-2072204
ABSTRACT
Objective There have been many efforts to research and produce treatment modalities for COVID-19. Monoclonal antibodies have been one of the effective treatments since their approval by the US Food and Drug Administration (FDA) under emergency use authorization (EUA) in 2020. This study surveyed COVID-19 patients about their disease course and experience with monoclonal antibody treatment. Methods Patients who received monoclonal antibody treatment between February 12, 2021, and June 2, 2021, at a South Florida community hospital were enrolled in the study. This included patients over 18 years of age with a confirmed positive COVID-19 test result, with mild to moderate symptoms within 10 days of onset and identified as high risk for progression to severe disease. There were no exclusion criteria. After 30 days, patients were followed up via a structured telephone survey regarding subsequent emergency department (ED) visits for worsening COVID-19 symptoms, need for oxygenation, intubation, and death. Secondary outcomes were adverse effects and patient perceptions. Results Among the 119 patients who received monoclonal antibodies during the established time frame, 93 (78.1%) consented to participate in the telephone survey. Of these, 11.8% had a subsequent visit to the ED for worsening COVID-19 symptoms, 6.5% required oxygen, and 2.2% were admitted to the intensive care unit (ICU). There were no reported intubations or deaths. The vast majority (91.4%) would recommend monoclonal antibody treatment to others. Conclusion Patients who received monoclonal antibody therapy had low rates of subsequent ED visits and rarely required oxygen or ICU admission. The majority of patients would recommend treatment with monoclonal antibodies to others.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Qualitative research Language: English Journal: Cureus Year: 2022 Document Type: Article Affiliation country: Cureus.29247

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Qualitative research Language: English Journal: Cureus Year: 2022 Document Type: Article Affiliation country: Cureus.29247