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TNF-? serum level between SARS-CoV-2 infected pregnant women with normal pregnant women in Dr. Soetomo General Hospital Surabaya
Bali Medical Journal ; 11(3):1059-1062, 2022.
Article in English | Web of Science | ID: covidwho-2072274
ABSTRACT

Background:

Pregnant women infected with SARS-CoV-2 experienced increased pro-inflammatory cytokines, including TNF-alpha, resulting in a cytokine storm condition. This study aimed to compare TNF-alpha levels between pregnant women infected and not infected with COVID-19 in the third trimester.

Method:

This observational research was conducted with cross sectional design. Our study included pregnant women who came to the delivery room/inpatient at Dr. Soetomo General Hospital Surabaya before or during labor between May and June 2021. The inclusion criteria were third trimester gestational age or >28 weeks with SARS-RT-PCR nasopharyngeal swab result. The exclusion criteria were all significant pregnancy complications. The pregnant woman coming to the delivery room will be screened for COVID-19, and blood samples will be examined using the flow cytometry method for the cytokine Th1 TNF-alpha.

Result:

There were no significant differences in TNF-alpha levels in pregnant women who were infected and not infected with COVID-19 (median 3.42 (7.24) pg/ml vs. 2.70 (3.06) pg/ml. p=0.138). There was also no significant difference in TNF-alpha levels in pregnant women with symptomatic vs. asymptomatic COVID-19 infection (3.21(3.97) vs. 2.41(2.71) pg/ml;p=0.314).

Conclusion:

This study revealed no significant difference in TNF-alpha serum level between SARS-CoV-2 infected pregnant women with normal pregnant women.
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Full text: Available Collection: Databases of international organizations Database: Web of Science Language: English Journal: Bali Medical Journal Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: Web of Science Language: English Journal: Bali Medical Journal Year: 2022 Document Type: Article