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The Association between the Fibrosis-4 Index and COVID-19: A Systematic Review and Meta-Analysis.
Ao, Guangyu; Li, Anthony; Li, Jing; Du, Xiaoli; Wang, Yushu; Tran, Carolyn; Qi, Xin.
  • Ao G; Department of Nephrology, Chengdu First People's Hospital, Chengdu, Sichuan, China.
  • Li A; School of Medicine, Queen's University, Kingston, Canada.
  • Li J; Department of Nephrology, Chengdu First People's Hospital, Chengdu, Sichuan, China.
  • Du X; Department of Radiology, Chengdu First People's Hospital, Chengdu, Sichuan, China.
  • Wang Y; West China Clinical Research Center, Chengdu, Sichuan, China.
  • Tran C; Schulich School of Medicine & Dentistry, Western University, London, Canada.
  • Qi X; Department of Neurology, the Affiliated Hospital of Southwest Jiaotong University and the Third People's Hospital of Chengdu, Chengdu, Sichuan, China qixinchengdu@163.com.
Ann Clin Lab Sci ; 52(5): 781-787, 2022 Sep.
Article in English | MEDLINE | ID: covidwho-2072746
ABSTRACT

OBJECTIVE:

The prognosis value of fibrosis-4 score (FIB-4) in COVID-19 is controversial. Hence, we conducted a systematic review and meta-analysis to investigate the association between the FIB-4 index and COVID-19 disease progression.

METHODS:

We performed meta-analysis using the PubMed, Embase, and Cochrane databases. A fixed- or random-effects model was used for evaluating heterogeneity.

RESULTS:

Thirteen studies were included. The meta-analysis of unadjusted results showed that compared to lower FIB-4 index, patients with higher FIB-4 index had increased odds of mortality (OR=5.1, 95%CI 3.67-7.09; P<0.001), ICU admission (OR=2.32, 95%CI 1.65-3.25, P<0.00001) and need for mechanical ventilator support (OR=3.51, 95%CI 2.1-5.85, P<0.001). In addition, the meta-analysis of adjusted results showed patients with higher FIB-4 index was associated with increased risk of mortality (OR=3.01, 95%CI 2.21-4.09, P<0.001) and need for mechanical ventilator support (OR=3.76, 95%CI 2.08-6.82, P<0.001) compared to patients with lower FIB-4 index.

CONCLUSIONS:

This meta-analysis indicated that high FIB-4 index score was associated with the severity and mortality in COVID-19 infected patients.
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Collection: International databases Database: MEDLINE Main subject: Fibrosis / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Ann Clin Lab Sci Year: 2022 Document Type: Article Affiliation country: China

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Collection: International databases Database: MEDLINE Main subject: Fibrosis / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Ann Clin Lab Sci Year: 2022 Document Type: Article Affiliation country: China