Rapidly Evolving and Fatal Miliary Tuberculosis and COVID-19 Infection in an Infant.
Ann Clin Lab Sci
; 52(5): 831-837, 2022 Sep.
Article
in English
| MEDLINE | ID: covidwho-2073089
ABSTRACT
Tuberculosis (TB) and SARS-CoV-2 (COVID-19) are two important infectious diseases causing morbidity and mortality worldwide. Active TB infection can stimulate host immune responses and together with COVID-19, may lead to cytokine storm and immune dysregulation leading to multi-organ failure. We present a rare case of both miliary tuberculosis and SARS-CoV-2 co-infection in an infant who was a 6-month-old previously healthy term boy. He had persistent cough and congestion, became severely ill, and was brought to the emergency department. He was found to be COVID-19 positive by PCR test. Laboratory studies showed pancytopenia, elevated inflammatory markers, and an abnormal coagulation profile with coagulopathy. He developed strokes, severe sepsis, and electrolyte abnormalities, and declined rapidly within 6 days. Autopsy examination showed multifocal micro-abscesses in multiple organs, which on microscopic examination showed necrotic foci teeming with Mycobacteria and were culture positive for M. tuberculosis Neuropathological examination showed infarction in the right middle and posterior cerebral artery territories. This patient helps illuminate some immunological and pathological aspects of two co-occurring infectious diseases and the susceptibility for the development of fatal complications with SARS-CoV-2 infection in the pediatric population.
Keywords
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Collection:
International databases
Database:
MEDLINE
Main subject:
Tuberculosis, Miliary
/
COVID-19
/
Mycobacterium tuberculosis
Type of study:
Case report
/
Diagnostic study
Topics:
Long Covid
Limits:
Child
/
Humans
/
Infant
/
Male
Language:
English
Journal:
Ann Clin Lab Sci
Year:
2022
Document Type:
Article
Affiliation country:
United States
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