Case series of chronic spontaneous urticaria following COVID-19 vaccines: an unusual skin manifestation.
Eur J Clin Pharmacol
; 78(12): 1959-1964, 2022 Dec.
Article
in English
| MEDLINE | ID: covidwho-2075334
ABSTRACT
BACKGROUND:
Urticaria following the COVID-19 vaccine was rarely reported and had a short self-limited resolution. However, there has been relatively little literature published on CSU induced by COVID-19 vaccines.PURPOSE:
We describe a case series of patients who experienced CSU after SARS-CoV-2 vaccination.METHODS:
A retrospective case series of 10 patients referred to the Department of Clinical Pharmacology of the University of Monastir (January 2021-January 2022) and included for evaluation of urticaria after COVID-19 vaccination.RESULTS:
The median age was 31 years and patients were mostly female. Atopy was presented in 3 patients and urticaria was accompanied by angioedema in 6 patients. The median time interval between vaccination and the onset of urticaria was 28.5 h. The offended dose was the first one in 8 patients. The resolution of the eruption was observed at least 2 months later, despite the regular use of a full dose of antihistamine in nine patients. Polynuclear leucocytosis was identified in 5 patients. Anti-TPOAb was positive in one patient after receiving the BNT162b2 vaccine. Total serum IgE was elevated in 4 patients. Skin tests for the suspected vaccine as well as the vaccine excipient were negative.CONCLUSION:
We add to the medical literature ten new cases of chronic spontaneous urticarial reactions following COVID-19 vaccines uncontrolled with high-dose first-generation H1 antihistamines.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Urticaria
/
Chronic Urticaria
/
COVID-19 Vaccines
/
COVID-19
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Topics:
Vaccines
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Eur J Clin Pharmacol
Year:
2022
Document Type:
Article
Affiliation country:
S00228-022-03399-8
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