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Genomic characterization and pathogenicity analysis of a porcine deltacoronavirus strain isolated in western China.
Wang, Zemei; Li, Shuxian; Shao, Yongheng; Lu, Yabin; Tan, Chen; Cui, Yaru; Ding, Guangming; Fu, Yuguang; Liu, Guangliang; Chen, Jianing; Hu, Yonghao.
  • Wang Z; College of Veterinary Medicine, Gansu Agricultural University, Ying-Men-Cun, Yin-Tan-Lu, An-Ning District, Lanzhou, 730000, Gansu, China.
  • Li S; State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 1 Xu-Jia-Ping, Yan-Chang-Bu, Cheng-Guan District, Lanzhou, 730046, Gansu, China.
  • Shao Y; State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 1 Xu-Jia-Ping, Yan-Chang-Bu, Cheng-Guan District, Lanzhou, 730046, Gansu, China.
  • Lu Y; College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, 830052, Xinjiang, China.
  • Tan C; College of Veterinary Medicine, Gansu Agricultural University, Ying-Men-Cun, Yin-Tan-Lu, An-Ning District, Lanzhou, 730000, Gansu, China.
  • Cui Y; State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 1 Xu-Jia-Ping, Yan-Chang-Bu, Cheng-Guan District, Lanzhou, 730046, Gansu, China.
  • Ding G; State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 1 Xu-Jia-Ping, Yan-Chang-Bu, Cheng-Guan District, Lanzhou, 730046, Gansu, China.
  • Fu Y; College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, 830052, Xinjiang, China.
  • Liu G; State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 1 Xu-Jia-Ping, Yan-Chang-Bu, Cheng-Guan District, Lanzhou, 730046, Gansu, China.
  • Chen J; State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 1 Xu-Jia-Ping, Yan-Chang-Bu, Cheng-Guan District, Lanzhou, 730046, Gansu, China.
  • Hu Y; State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 1 Xu-Jia-Ping, Yan-Chang-Bu, Cheng-Guan District, Lanzhou, 730046, Gansu, China.
Arch Virol ; 167(11): 2249-2262, 2022 Nov.
Article in English | MEDLINE | ID: covidwho-2075433
ABSTRACT
Porcine deltacoronavirus (PDCoV) is an enteric virus that was first identified in 2012. Although PDCoV has been detected worldwide, there is little information about its circulation in western China. In this study, fecal samples were collected from piglets with watery diarrhea in western China between 2015 and 2018 for the detection of PDCoV. The positive rate was 29.9%. A PDCoV strain (CHN/CQ/BN23/2016, BN23) was isolated and selected for further investigation. Phylogenetic analysis showed that this strain formed an individual cluster between the early Chinese lineage and the Chinese lineage. RDP4 and SimPlot analysis demonstrated that strain BN23 is a recombinant of Thailand/S5015L/2015 and CHN-AH-2004. The pathogenicity of BN23 was evaluated in 3-day-old piglets. Challenged piglets developed serious clinical signs and died at 3 days post-inoculation. Our data show that PDCoV is prevalent in western China and that strain BN23 is highly pathogenic to newborn piglets. Therefore, more attention should be paid to emerging PDCoV strains in western China.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Deltacoronavirus Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Animals Country/Region as subject: Asia Language: English Journal: Arch Virol Year: 2022 Document Type: Article Affiliation country: S00705-022-05549-w

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Deltacoronavirus Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Animals Country/Region as subject: Asia Language: English Journal: Arch Virol Year: 2022 Document Type: Article Affiliation country: S00705-022-05549-w