Key molecules of Mucorales for COVID-19-associated mucormycosis: a narrative review
Journal of Bio-X Research
; 5(3):104-111, 2022.
Article
in English
| EMBASE | ID: covidwho-2077937
ABSTRACT
Mucormycosis is a lethal human disease caused by fungi of the order Mucorales. Mucormycosis is caused by fungi mainly belonging to the genera Mucor, Rhizopus, and Lichtheimia, all of which belong to the order Mucorales. The number of individuals with mucormycosis-causing disorders has increased in recent years, hence, leading to the spread of mucormycosis. Throughout the coronavirus disease 2019 (COVID-19) pandemic, numerous cases of mucormycosis in COVID-19-infected patients have been reported worldwide, and the illness is now recognized as COVID-19-associated mucormycosis, with most of the cases being reported from India. Immunocompromised patients such as those with bone marrow sickness and uncontrolled diabetes are at a greater risk of developing mucormycosis. Genes, pathways, and other mechanisms have been studied in Mucorales, demonstrating a direct link between virulence and prospective therapeutic and diagnostic targets. This review discusses several proteins such as high-affinity iron permease (FTR1), calcineurin, spore coat protein (CotH), and ADP-ribosylation factors involved in the pathogenesis of mucormycosis that might prove to be viable target(s) for the development of novel diagnostic and therapeutic methods. Copyright © 2022 The Chinese Medical Association, Published by Wolters Kluwer Health, Inc.
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Reviews
Language:
English
Journal:
Journal of Bio-X Research
Year:
2022
Document Type:
Article
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