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Enhancing Clinical Diagnosis for Patients With Persistent Pulmonary Abnormalities After COVID-19 Infection: The Potential Benefit of 68 Ga-FAPI PET/CT.
Sviridenko, Anna; Boehm, Anna; di Santo, Gianpaolo; Uprimny, Christian; Nilica, Bernhard; Fritz, Josef; Giesel, Frederik L; Haberkorn, Uwe; Sahanic, Sabina; Decristoforo, Clemens; Tancevski, Ivan; Widmann, Gerlig; Loeffler-Ragg, Judith; Virgolini, Irene.
  • Sviridenko A; From the Departments of Nuclear Medicine.
  • Boehm A; Internal Medicine II.
  • di Santo G; From the Departments of Nuclear Medicine.
  • Uprimny C; From the Departments of Nuclear Medicine.
  • Nilica B; From the Departments of Nuclear Medicine.
  • Fritz J; Radiology, Medical University of Innsbruck, Innsbruck, Austria.
  • Haberkorn U; Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg.
  • Sahanic S; Internal Medicine II.
  • Decristoforo C; From the Departments of Nuclear Medicine.
  • Tancevski I; Internal Medicine II.
  • Widmann G; Department of Medical Statistic and Informatics, Medical University of Innsbruck, Innsbruck, Austria.
  • Loeffler-Ragg J; Internal Medicine II.
  • Virgolini I; From the Departments of Nuclear Medicine.
Clin Nucl Med ; 47(12): 1026-1029, 2022 Dec 01.
Article in English | MEDLINE | ID: covidwho-2078007
ABSTRACT
PATIENTS AND

METHODS:

Six post COVID-19 patients suspected for pulmonary fibrosis were scheduled for dual-tracer PET/CT with 18 F-FDG and 68 Ga-fibroblast activation protein inhibitor (FAPI)-46. The uptake of 68 Ga-FAPI-46 in the involved lung was compared with a control group of 9 non-COVID-19 patients. Clinical data and PET/CT imaging were collected and analyzed.

RESULTS:

PET/CT revealed in all 6 pulmonary impaired patients the reduced glucose avidity on 18 F-FDG and clear positivity on 68 Ga-FAPI-46 PET/CT in comparison to the control group.

CONCLUSIONS:

Enhancing fibrotic repair mechanisms, 68 Ga-FAPI PET/CT may improve noninvasive clinical diagnostic performance in patients with long-term CT abnormalities after severe COVID-19. Although this study shows promising results, additional studies in larger populations are required to establish a general diagnostic guideline.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Positron Emission Tomography Computed Tomography / COVID-19 Type of study: Experimental Studies / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Clin Nucl Med Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Positron Emission Tomography Computed Tomography / COVID-19 Type of study: Experimental Studies / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Clin Nucl Med Year: 2022 Document Type: Article