Preliminary results after developing of a protocol of treatment of acute non complicated diverticulits without antibiotherapy
Colorectal Disease
; 24(Supplement 3):96, 2022.
Article
in English
| EMBASE | ID: covidwho-2078395
ABSTRACT
Aim:
To confirm safety of treatment of acute uncomplicated diverticulitis (AUD) without antibiotics, developing a standarized protocol for selected patients. Method(s) Prospective observational multicentre study carried out between january 1st 2021 and april 15th 2022. Inclusion criteria Age between 18 and 80, AUD diagnosed by computarized tomography (CT), adequate family support and cognitive capacity, good symptom control, adequate oral intake, signed informed consent. Exclusion criteria diabetes mellitus, cardiologic event in the last 3 months, chronic liver disease, advanced chronic renal failure, active neoplasic pathology, HIV active infection, corticoidsteroid or immunosuppresant therapy, transplant, splenectomy, inflamatory bowel disease, previous episode of diverticulitis during last 3 months and antibiotic treatment during last 2weeks. Maximum 1 of the following T >38degreeC-<36degreeC, L >12,000/ml-<4000/ ml, heart rate>90 bpm, CPR >15 mg/dL. Patients were proposed to take part of the study and those who accepted were treated as outpatient with ibuprofen 600mg/8 h, paracetamol 1 g/8 h and omeprazol 40 mg/24h during 7days. Follow-up was carried out by telephone during first 24 h, and attending the emergency department at 48 h and at 7days. Result(s) 157 patients were diagnosed of acute diverticulits, 132 were Hinchey Ia, with 37 (28.1%) patients that fullfilled criteria for the study. 67.6% of patients were male, with median age of 57.6+/-9.7years. Among 37 patients included in the study, 36 were contacted by telephone 24 h. after first visit to emergency department. Only one of them had fever 48 h after diagnosis all patients were clinically reevaluated and only two of them needed a change of strategy, one because of fever, so we started antibiotic therapy and the other because COVID-19 infection. None of the patients needed urgent surgical intervention nor hospitalisation during the study and follow up. Conclusion(s) Our results confirm that treatment of AUD without antibiotics in selected patients is safe.
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Colorectal Disease
Year:
2022
Document Type:
Article
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