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Additional Evidence for Commonalities between COVID-19 and Radiation Injury: Novel Insight into COVID-19 Candidate Drugs.
Geng, Fenghao; Chen, Jianhui; Tang, Shaokai; Azzam, Edouard I; Zhang, Jie; Zhang, Shuyu.
  • Geng F; West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China.
  • Chen J; West China Second University Hospital, Sichuan University, Chengdu 610041, China.
  • Tang S; West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China.
  • Azzam EI; West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China.
  • Zhang J; Radiobiology and Health, Isotopes, Radiobiology & Environment Directorate (IRED), Canadian Nuclear Laboratories (CNL), Chalk River, ON K0J 1J0, Canada.
  • Zhang S; Institute of Preventive Medicine, Fourth Military Medical University, Xi'an 710032, China.
Radiat Res ; 198(3): 306-317, 2022 09 01.
Article in English | MEDLINE | ID: covidwho-2079878
ABSTRACT
COVID-19 is a challenge to biosecurity and public health. The speed of vaccine development lags behind that of virus evolution and mutation. To date, no agent has been demonstrated to be fully effective against COVID-19. Therefore, it remains of great urgency to rapidly develop promising therapeutic and diagnostic candidates. Intriguingly, mounting evidence hints at parallel etiologies between SARS-CoV-2 infection and radiation injury. Herein, from the perspectives of immunogenic pathway activation and metabolic alterations, we provide novel evidence of commonalities between these two pathological conditions based on the most recent findings. Since numerous agents have been developed to prevent or reverse radiation injury in the past 70 years to ensure nuclear safety, we also advocate investigating the promising function of radioprotectors and radiomitigators against COVID-19 in clinical settings.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Radiation Injuries / COVID-19 Type of study: Etiology study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Radiat Res Year: 2022 Document Type: Article Affiliation country: RADE-22-00058.1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Radiation Injuries / COVID-19 Type of study: Etiology study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Radiat Res Year: 2022 Document Type: Article Affiliation country: RADE-22-00058.1