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Effects of Vaccination Against Influenza, Pertussis, and COVID-19 on Human Milk Antibodies: Current Evidence and Implications for Health Equity.
Hunagund, Soumya; Golan, Yarden; Asiodu, Ifeyinwa V; Prahl, Mary; Gaw, Stephanie L.
  • Hunagund S; Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, United States.
  • Golan Y; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United States.
  • Asiodu IV; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, United States.
  • Prahl M; Department of Family Health Care Nursing, University of California, San Francisco, San Francisco, CA, United States.
  • Gaw SL; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, United States.
Front Immunol ; 13: 910383, 2022.
Article in English | MEDLINE | ID: covidwho-2080130
ABSTRACT
Human milk contains three antibody classes that confer mucosal immunity to the breastfed infant secretory IgA (SIgA), secretory IgM (SIgM), and IgG. Influenza and pertussis vaccines administered during pregnancy induce pathogen specific SIgA and IgG responses in human milk that have been shown to protect the breastfed infant from these respiratory illnesses. In addition, mRNA vaccines against the SARS-CoV-2 virus administered during pregnancy and lactation induce anti-SARS-CoV-2 IgG and IgA responses in human milk. This review summarizes the immunologic benefits of influenza, pertussis, and COVID-19 vaccines conferred by human milk. Additionally, future research direction in human milk immunity and public health needs to improve lactational support are discussed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / Whooping Cough / Health Equity / Influenza, Human / COVID-19 Type of study: Experimental Studies Topics: Vaccines Limits: Female / Humans / Infant / Pregnancy Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.910383

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / Whooping Cough / Health Equity / Influenza, Human / COVID-19 Type of study: Experimental Studies Topics: Vaccines Limits: Female / Humans / Infant / Pregnancy Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.910383