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COVID-19 Vaccination-Induced Cholangiopathy and Autoimmune Hepatitis: A Series of Two Cases.
Zafar, Mansoor; Gordon, Katherine; Macken, Lucia; Parvin, Joe; Heath, Simon; Whibley, Max; Tibble, Jeremy.
  • Zafar M; Gastroenterology/General Internal Medicine, Royal Sussex County Hospital, University Hospitals Sussex National Health Service (NHS) Foundation Trust, Brighton, GBR.
  • Gordon K; Gastroenterology, Royal Sussex County Hospital, University Hospitals Sussex National Health Service (NHS) Foundation Trust, Brighton, GBR.
  • Macken L; Gastroenterology, Royal Sussex County Hospital, University Hospitals Sussex National Health Service (NHS) Foundation Trust, Brighton, GBR.
  • Parvin J; Gastroenterology/General Internal Medicine, Royal Sussex County Hospital, University Hospitals Sussex National Health Service (NHS) Foundation Trust, Brighton, GBR.
  • Heath S; Cellular Pathology, Royal Sussex County Hospital, University Hospitals Sussex National Health Service (NHS) Foundation Trust, Brighton, GBR.
  • Whibley M; Cellular Pathology, Royal Sussex County Hospital, University Hospitals Sussex National Health Service (NHS) Foundation Trust, Brighton, GBR.
  • Tibble J; Gastroenterology/Hepatology, Royal Sussex County Hospital, University Hospitals Sussex National Health Service (NHS) Foundation Trust, Brighton, GBR.
Cureus ; 14(10): e30304, 2022 Oct.
Article in English | MEDLINE | ID: covidwho-2080880
ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic has been associated with significant morbidity and mortality. Following the introduction of vaccines, various side effects have been reported. Whilst those reported may be attributed to the vaccine itself, at times, it may simply incite an immunological phenomenon. We present a case series of two patients who presented with symptoms of yellowing of the eyes and the skin along with fatigue, and tiredness, following vaccination for COVID-19. The diagnosis of post COVID-19-vaccination related hepatitis is one of the fewer, less understood, yet reported side effects associated with significant morbidity. The diagnosis of COVID-19 vaccination-related cholangitis is an outcome reported here for the first time to the best of our knowledge. It was alarming that both patients did not have any significant past history of medical ailments. A prompt assessment followed by investigations including liver biopsy assisted in a timely understanding of the phenomenon with complete resolution of the symptoms.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Prognostic study Topics: Long Covid / Vaccines Language: English Journal: Cureus Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Prognostic study Topics: Long Covid / Vaccines Language: English Journal: Cureus Year: 2022 Document Type: Article