termination of xanthine, hypoxanthine and c- reactive protein in the serum of patients of coronavirus and patients vaccinated with fizer

ABSTRACT

Background: The coronavirus associated with severe acute respiratory syndrome type 2 causes Coronavirus disease 2019 (COVID-19) (SARS-CoV-2). Xanthine is a purine nucleotide that is found in the majority of human tissues and fluids, as well as other biota. Hypoxanthine is a purine derivative that occurs naturally. C-reactive protein (CRP) is an annular (ring-shaped) pentameric protein that is detected in blood plasma and whose circulating levels increase in response to inflammation. The aim of the current study is evaluation of serum (Xanthine, Hypoxanthine, and C-RP) patients of COVID-19 (vaccinated and unvaccinated) with P-fizer vaccine.Methods: The study was done in Babylon University/College of Science. Study continued five months from 3-1 to 3-5 - 2022.. 150 samples of blood were obtained from three groups.50 blood samples were obtained from healthy people (group I), 50 blood samples were drawn from COVID-19 patients unvaccinated (group II), and 50 samples were obtained from COVID-19 patients vaccinated with P-fizer (group III). The target parameters were (Xanthine, Hypoxanthine, and C-RP). (Xanthine and Hypoxanthine) were measured by HPLC instruments. C-RP was measured by the ichroma instrument.Results: The result showed age was shown to be not significant between groups. Xanthine showed a significant increase in the non-vaccinated group of patients compared to the rest of the groups, where it was 2.16 ± 0.02, While in the vaccinated group, it was 0.68 ± 0.01. Hypoxanthine also showed a significant increase in unvaccinated patients. CRP showed a significant increase in unvaccinated patients.Conclusion: The current study concluded that the Pfizer vaccine had an effect on (Xanthine, Hypoxanthine,C-reactive protein (CRP)) concentrations for the better in the vaccinated group of patients. © 2022, ResearchTrentz Academy Publishing Education Services. All rights reserved.