Correlation of D-Dimer Level with Severity of Pneumonia, Hospital Stay and Mortality in Case of Covid-19 Infection: A Retrospective Study an a Tertiary Care Hospital

ABSTRACT

Introduction: Worldwide there was a pandemic of novel corona virus infection in which one of the major concern was the risk of thrombosis and the mortality associated with it. Aim(s) In this study our aim was to observe the changes in D-dimer levels during disease progression and its correlations with severity of Pneumonia, duration of hospital stay and mortality of COVID-19 patients. Material(s) and Method(s) In this study we reported the clinical, radiological and pathological laboratory results of 432 cases of confirmed COVID-19 infection. In these patients their clinical presentation, concentration of D-dimer, coagulation parameters, CBC, severity of Pneumonia on HRCT, hospital stay and higher mortality were retrospectively analyzed. Result(s) All the statistical variables were expressed in % and compared withx2 test. Out of the 432 cases in 45 cases (10.41%) the D-dimer values were >2.4microg/ml and in 15 cases the value were very high (3.47%). When correlated these patients found to have severe degree of pneumonia, longer hospital stay and higher mortality rate in comparison to patients with D-dimer level of <2.4 microg/ml. Conclusion(s) D-dimer level could be used as an early marker for the clinical classification, risk stratification and improved management of COVID-19 patients. Copyright © 2022, Institute of Medico-legal Publication. All rights reserved.