Apigenin inhibits infectious bronchitis virus replication in ovo
European Review for Medical and Pharmacological Sciences
; 26(15):5367-5371, 2022.
Article
in English
| Web of Science | ID: covidwho-2081696
ABSTRACT
OBJECTIVE:
Infectious bronchi-tis virus (IBV), for which no effective drugs are available, is among the most important causes of economic loss within the poultry industry. Apigenin is a flavonoid that can be isolated from plants. Apigenin has low toxicity with anti-viral activity. However, the effects of apigenin against IBV remain unclear. MATERIALS ANDMETHODS:
Thus, here we investigate the anti-viral effect of apigenin on IBV using 10 day-old embryonated eggs by determining the virus titer by embryo infective doses50 (EID50/mL) and determining IBV genomes copy number (per mu L) of allantoic fluid.RESULTS:
We found that apigenin protected embryonated eggs from IBV. Additionally, apigenin reduced the log titer of the IBV with a significant correlation of up to 9.4 times at 2 mu g/ egg. Also, apigenin appears to significantly re-duce IBV genomes copy number (per mu L) in the allantoic fluid.CONCLUSIONS:
Apigenin may be a promising approach for the treatment of IBV, since it protects embryonated eggs from IBV in ovo and suppresses viral replication.
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Collection:
Databases of international organizations
Database:
Web of Science
Language:
English
Journal:
European Review for Medical and Pharmacological Sciences
Year:
2022
Document Type:
Article
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