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Bacterial Pulmonary Co-Infections on ICU Admission: Comparison in Patients with SARS-CoV-2 and Influenza Acute Respiratory Failure: A Multicentre Cohort Study.
Delhommeau, Grégoire; Buetti, Niccolò; Neuville, Mathilde; Siami, Shidasp; Cohen, Yves; Laurent, Virginie; Mourvillier, Bruno; Reignier, Jean; Goldgran-Toledano, Dany; Schwebel, Carole; Ruckly, Stéphane; de Montmollin, Etienne; Souweine, Bertrand; Timsit, Jean-François; Dupuis, Claire.
  • Delhommeau G; Service de Pneumologie, CHU Gabriel Montpied, 63000 Clermont-Ferrand, France.
  • Buetti N; Unité Mixte de Recherche (UMR) 1137, IAME, Université Paris Cité, 75018 Paris, France.
  • Neuville M; Infection Control Program and WHO Collaborating Centre on Patient Safety, Faculty of Medicine, University of Geneva Hospitals, 1205 Geneva, Switzerland.
  • Siami S; Polyvalent Intensive Care Unit, Hôpital Foch, 92150 Suresnes, France.
  • Cohen Y; General Intensive Care Unit, Sud Essonne Hospital, 91150 Etampes, France.
  • Laurent V; Intensive Care Unit, University Hospital Avicenne, AP-HP, 93000 Bobigny, France.
  • Mourvillier B; Polyvalent Intensive Care Unit, André Mignot Hospital, 78150 Le Chesnay, France.
  • Reignier J; Medical Intensive Care Unit, University Hospital of Reims, 51100 Reims, France.
  • Goldgran-Toledano D; Medical Intensive Care Unit, University Hospital of Nantes, 44000 Nantes, France.
  • Schwebel C; Medical and Surgical Intensive Care, Montfermeil Hospital, 93370 Montfermeil, France.
  • Ruckly S; Medical Intensive Care Unit, University Hospital Grenoble-Alpes, 38000 Grenoble, France.
  • de Montmollin E; Unité Mixte de Recherche (UMR) 1137, IAME, Université Paris Cité, 75018 Paris, France.
  • Souweine B; Unité Mixte de Recherche (UMR) 1137, IAME, Université Paris Cité, 75018 Paris, France.
  • Timsit JF; Medical and Infectious Diseases Intensive Care Unit, Bichat Hospital, AP-HP, 75018 Paris, France.
  • Dupuis C; Medical Intensive Care Unit, University Hospital Gabriel Montpied, 63000 Clermont-Ferrand, France.
Biomedicines ; 10(10)2022 Oct 20.
Article in English | MEDLINE | ID: covidwho-2081923
ABSTRACT

BACKGROUND:

Few data are available on the impact of bacterial pulmonary co-infection (RespCoBact) during COVID-19 (CovRespCoBact). The aim of this study was to compare the prognosis of patients admitted to an ICU for influenza pneumonia and for SARS-CoV-2 pneumonia with and without RespCoBact.

METHODS:

This was a multicentre (n = 11) observational study using the Outcomerea© database. Since 2008, all patients admitted with influenza pneumonia or SARS-CoV-2 pneumonia and discharged before 30 June 2021 were included. Risk factors for day-60 death and for ventilator-associated-pneumonia (VAP) in patients with influenza pneumonia or SARS-CoV-2 pneumonia with or without RespCoBact were determined.

RESULTS:

Of the 1349 patients included, 157 were admitted for influenza and 1192 for SARS-CoV-2. Compared with the influenza patients, those with SARS-CoV-2 had lower severity scores, were more often under high-flow nasal cannula, were less often under invasive mechanical ventilation, and had less RespCoBact (8.2% for SARS-CoV-2 versus 24.8% for influenza). Day-60 death was significantly higher in patients with SARS-CoV-2 pneumonia with no increased risk of mortality with RespCoBact. Patients with influenza pneumonia and those with SARS-CoV-2 pneumonia had no increased risk of VAP with RespCoBact.

CONCLUSIONS:

SARS-CoV-2 pneumonia was associated with an increased risk of mortality compared with Influenza pneumonia. Bacterial pulmonary co-infections on admission were not associated with patient survival rates nor with an increased risk of VAP.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Biomedicines10102646

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Biomedicines10102646