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High Prevalence of Undocumented SARS-CoV-2 Infections in the Pediatric Population of the Tyrolean District of Schwaz.
Harthaller, Teresa; Borena, Wegene; Bante, David; Schäfer, Helena; Strallhofer, Oliver; Zöggeler, Thomas; Hochmuth, Eva; Hoch, Luiza; Rössler, Annika; von Laer, Dorothee; Kimpel, Janine; Falkensammer, Barbara.
  • Harthaller T; Institute of Virology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
  • Borena W; Institute of Virology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
  • Bante D; Institute of Virology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
  • Schäfer H; Institute of Virology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
  • Strallhofer O; Dr. Strallhofer's Office, 6200 Jenbach, Austria.
  • Zöggeler T; Department of Pediatrics I, Medical University of Innsbruck, 6020 Innsbruck, Austria.
  • Hochmuth E; Institute of Virology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
  • Hoch L; Institute of Virology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
  • Rössler A; Institute of Virology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
  • von Laer D; Institute of Virology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
  • Kimpel J; Institute of Virology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
  • Falkensammer B; Institute of Virology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Viruses ; 14(10)2022 10 19.
Article in English | MEDLINE | ID: covidwho-2081992
ABSTRACT
Complementing the adult seroprevalence data collected at the time of the rapid SARS-CoV-2 mass vaccination in the district of Schwaz in 2021, we set out to establish the seroprevalence of SARS-CoV-2 among the pediatric population of the district. A total of 369 children, mean age 9.9 (SD 3.4), participated in the study, answering a structured questionnaire on the history of SARS-CoV-2 infection, household contacts, symptoms and history of vaccination. We determined binding and neutralizing antibody levels using plasma samples provided. We estimated the overall prevalence of SARS-CoV-2 infection in the general pediatric population at the time of the study using the census data from Statistik Austria and daily reports of officially confirmed cases. Excluding study participants who reported a history of PCR-confirmed infection, the age-standardized seroprevalence of previously unknown SARS-CoV-2 infection among the general pediatric population of the district was 27% (95% CI 26.1-27.8). Adding this to the officially documented cases, the true overall prevalence was 32.8% (95% CI 31.9-33.6) in contrast to the officially documented 8.0% (95% CI 7.5-8.5) by June 2021. This translated into a proportion of 75.7% (95% CI 74.4-77.0) of cases being officially undocumented, suggesting a high extent of silent SARS-CoV-2 infections in the pediatric population and possibly silent transmission.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study / Qualitative research Topics: Vaccines Limits: Adult / Child / Humans Language: English Year: 2022 Document Type: Article Affiliation country: V14102294

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study / Qualitative research Topics: Vaccines Limits: Adult / Child / Humans Language: English Year: 2022 Document Type: Article Affiliation country: V14102294