Your browser doesn't support javascript.
An Update on Detection Technologies for SARS-CoV-2 Variants of Concern.
Jiang, Wenjie; Ji, Wangquan; Zhang, Yu; Xie, Yaqi; Chen, Shuaiyin; Jin, Yuefei; Duan, Guangcai.
  • Jiang W; Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
  • Ji W; Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
  • Zhang Y; Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
  • Xie Y; Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
  • Chen S; Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
  • Jin Y; Henan Key Laboratory of Molecular Medicine, Zhengzhou University, Zhengzhou 450001, China.
  • Duan G; Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Viruses ; 14(11)2022 Oct 22.
Article in English | MEDLINE | ID: covidwho-2082026
ABSTRACT
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is responsible for the global epidemic of Coronavirus Disease 2019 (COVID-19), with a significant impact on the global economy and human safety. Reverse transcription-quantitative polymerase chain reaction (RT-PCR) is the gold standard for detecting SARS-CoV-2, but because the virus's genome is prone to mutations, the effectiveness of vaccines and the sensitivity of detection methods are declining. Variants of concern (VOCs) include Alpha, Beta, Gamma, Delta, and Omicron, which are able to evade recognition by host immune mechanisms leading to increased transmissibility, morbidity, and mortality of COVID-19. A range of research has been reported on detection techniques for VOCs, which is beneficial to prevent the rapid spread of the epidemic, improve the effectiveness of public health and social measures, and reduce the harm to human health and safety. However, a meaningful translation of this that reduces the burden of disease, and delivers a clear and cohesive message to guide daily clinical practice, remains preliminary. Herein, we summarize the capabilities of various nucleic acid and protein-based detection methods developed for VOCs in identifying and differentiating current VOCs and compare the advantages and disadvantages of each method, providing a basis for the rapid detection of VOCs strains and their future variants and the adoption of corresponding preventive and control measures.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Epidemics / COVID-19 Type of study: Diagnostic study / Prognostic study Topics: Vaccines / Variants Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: V14112324

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Epidemics / COVID-19 Type of study: Diagnostic study / Prognostic study Topics: Vaccines / Variants Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: V14112324