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Impact of Early Pandemic SARS-CoV-2 Lineages Replacement with the Variant of Concern P.1 (Gamma) in Western Bahia, Brazil.
Pinheiro, Josilene R; Dos Reis, Esther C; Farias, Jéssica P; Fogaça, Mayanna M C; da Silva, Patrícia de S; Santana, Itana Vivian R; Rocha, Ana Luiza S; Vidal, Paloma O; Simões, Rafael da C; Luiz, Wilson B; Birbrair, Alexander; de Aguiar, Renato S; de Souza, Renan P; Azevedo, Vasco A de C; Chaves, Gepoliano; Belmok, Aline; Durães-Carvalho, Ricardo; Melo, Fernando L; Ribeiro, Bergmann M; Amorim, Jaime Henrique.
  • Pinheiro JR; Center of Biological Sciences and Health, Federal University of Western Bahia, Barreiras 47805, BA, Brazil.
  • Dos Reis EC; Department of Biological Sciences, State University of Santa Cruz, Ilhéus 45662, BA, Brazil.
  • Farias JP; Center of Biological Sciences and Health, Federal University of Western Bahia, Barreiras 47805, BA, Brazil.
  • Fogaça MMC; Center of Biological Sciences and Health, Federal University of Western Bahia, Barreiras 47805, BA, Brazil.
  • da Silva PS; Center of Biological Sciences and Health, Federal University of Western Bahia, Barreiras 47805, BA, Brazil.
  • Santana IVR; Center of Biological Sciences and Health, Federal University of Western Bahia, Barreiras 47805, BA, Brazil.
  • Rocha ALS; Department of Biological Sciences, State University of Santa Cruz, Ilhéus 45662, BA, Brazil.
  • Vidal PO; Center of Biological Sciences and Health, Federal University of Western Bahia, Barreiras 47805, BA, Brazil.
  • Simões RDC; Center of Biological Sciences and Health, Federal University of Western Bahia, Barreiras 47805, BA, Brazil.
  • Luiz WB; Center of Biological Sciences and Health, Federal University of Western Bahia, Barreiras 47805, BA, Brazil.
  • Birbrair A; Center of Biological Sciences and Health, Federal University of Western Bahia, Barreiras 47805, BA, Brazil.
  • de Aguiar RS; Department of Biological Sciences, State University of Santa Cruz, Ilhéus 45662, BA, Brazil.
  • de Souza RP; Department of Dermatology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA.
  • Azevedo VAC; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte 31270, MG, Brazil.
  • Chaves G; Department of Radiology, Columbia University Medical Center, New York, NY 10032, USA.
  • Belmok A; Department of Genetics, Ecology and Evolution, Federal University of Minas Gerais, Belo Horizonte 31270, MG, Brazil.
  • Durães-Carvalho R; D'Or Institute of Research, Rio de Janeiro 22281, RJ, Brazil.
  • Melo FL; Department of Genetics, Ecology and Evolution, Federal University of Minas Gerais, Belo Horizonte 31270, MG, Brazil.
  • Ribeiro BM; Department of Genetics, Ecology and Evolution, Federal University of Minas Gerais, Belo Horizonte 31270, MG, Brazil.
  • Amorim JH; Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA.
Viruses ; 14(10)2022 10 21.
Article in English | MEDLINE | ID: covidwho-2082182
ABSTRACT

BACKGROUND:

The correct understanding of the epidemiological dynamics of COVID-19, caused by the SARS-CoV-2, is essential for formulating public policies of disease containment.

METHODS:

In this study, we constructed a picture of the epidemiological dynamics of COVID-19 in a Brazilian population of almost 17000 patients in 15 months. We specifically studied the fluctuations of COVID-19 cases and deaths due to COVID-19 over time according to host gender, age, viral load, and genetic variants.

RESULTS:

As the main results, we observed that the numbers of COVID-19 cases and deaths due to COVID-19 fluctuated over time and that men were the most affected by deaths, as well as those of 60 or more years old. We also observed that individuals between 30- and 44-years old were the most affected by COVID-19 cases. In addition, the viral loads in the patients' nasopharynx were higher in the early symptomatic period. We found that early pandemic SARS-CoV-2 lineages were replaced by the variant of concern (VOC) P.1 (Gamma) in the second half of the study period, which led to a significant increase in the number of deaths.

CONCLUSIONS:

The results presented in this study are helpful for future formulations of efficient public policies of COVID-19 containment.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study Topics: Variants Limits: Adult / Humans / Male / Middle aged Country/Region as subject: South America / Brazil Language: English Year: 2022 Document Type: Article Affiliation country: V14102314

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study Topics: Variants Limits: Adult / Humans / Male / Middle aged Country/Region as subject: South America / Brazil Language: English Year: 2022 Document Type: Article Affiliation country: V14102314