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Antigenic cartography of well-characterized human sera shows SARS-CoV-2 neutralization differences based on infection and vaccination history.
Wang, Wei; Lusvarghi, Sabrina; Subramanian, Rahul; Epsi, Nusrat J; Wang, Richard; Goguet, Emilie; Fries, Anthony C; Echegaray, Fernando; Vassell, Russell; Coggins, Si'Ana A; Richard, Stephanie A; Lindholm, David A; Mende, Katrin; Ewers, Evan C; Larson, Derek T; Colombo, Rhonda E; Colombo, Christopher J; Joseph, Janet O; Rozman, Julia S; Smith, Alfred; Lalani, Tahaniyat; Berjohn, Catherine M; Maves, Ryan C; Jones, Milissa U; Mody, Rupal; Huprikar, Nikhil; Livezey, Jeffrey; Saunders, David; Hollis-Perry, Monique; Wang, Gregory; Ganesan, Anuradha; Simons, Mark P; Broder, Christopher C; Tribble, David R; Laing, Eric D; Agan, Brian K; Burgess, Timothy H; Mitre, Edward; Pollett, Simon D; Katzelnick, Leah C; Weiss, Carol D.
  • Wang W; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA.
  • Lusvarghi S; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA.
  • Subramanian R; Office of Data Science and Emerging Technologies, Office of Science Management and Operations, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Epsi NJ; Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
  • Wang R; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA.
  • Goguet E; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
  • Fries AC; U.S. Air Force School of Aerospace Medicine, Wright-Patterson Air Force Base, Fairborn, OH, USA.
  • Echegaray F; Viral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Vassell R; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA.
  • Coggins SA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
  • Richard SA; Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
  • Lindholm DA; Brooke Army Medical Center, Joint Base San Antonio-Fort Sam Houston, San Antonio, TX, USA; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
  • Mende K; Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
  • Ewers EC; Fort Belvoir Community Hospital, Fort Belvoir, VA, USA.
  • Larson DT; Fort Belvoir Community Hospital, Fort Belvoir, VA, USA.
  • Colombo RE; Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA; Department of Medicine, Uniforme
  • Colombo CJ; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; Madigan Army Medical Center, Tacoma, WA, USA.
  • Joseph JO; Viral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Rozman JS; Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
  • Smith A; Naval Medical Center Portsmouth, Portsmouth, VA, USA.
  • Lalani T; Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA; Naval Medical Center Portsmouth,
  • Berjohn CM; Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; Naval Medical Center San Diego
  • Maves RC; Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; Section of Infectious Diseases
  • Jones MU; Tripler Army Medical Center, Honolulu, HI, USA.
  • Mody R; William Beaumont Army Medical Center, El Paso, TX, USA.
  • Huprikar N; Walter Reed National Military Medical Center, Bethesda, MD, USA.
  • Livezey J; Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
  • Saunders D; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
  • Hollis-Perry M; Clinical Trials Center, Infectious Diseases Directorate, Naval Medical Research Center, Silver Spring, MD, USA.
  • Wang G; General Dynamics Information Technology, Falls Church, VA, USA.
  • Ganesan A; Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA; Walter Reed National Military Me
  • Simons MP; Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
  • Broder CC; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
  • Tribble DR; Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
  • Laing ED; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
  • Agan BK; Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
  • Burgess TH; Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
  • Mitre E; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
  • Pollett SD; Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA. Electronic address: spollett@idc
  • Katzelnick LC; Viral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address: leah.katzelnick@nih.gov.
  • Weiss CD; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA. Electronic address: carol.weiss@fda.hhs.gov.
Cell Host Microbe ; 2022 Oct 21.
Article in English | MEDLINE | ID: covidwho-2118002
ABSTRACT
The rapid emergence of SARS-CoV-2 variants challenges vaccination strategies. Here, we collected 201 serum samples from persons with a single infection or multiple vaccine exposures, or both. We measured their neutralization titers against 15 natural variants and 7 variants with engineered spike mutations and analyzed antigenic diversity. Antigenic maps of primary infection sera showed that Omicron sublineages BA.2, BA.4/BA.5, and BA.2.12.1 are distinct from BA.1 and more similar to Beta/Gamma/Mu variants. Three mRNA COVID-19 vaccinations increased neutralization of BA.1 more than BA.4/BA.5 or BA.2.12.1. BA.1 post-vaccination infection elicited higher neutralization titers to all variants than three vaccinations alone, although with less neutralization to BA.2.12.1 and BA.4/BA.5. Those with BA.1 infection after two or three vaccinations had similar neutralization titer magnitude and antigenic recognition. Accounting for antigenic differences among variants when interpreting neutralization titers can aid the understanding of complex patterns in humoral immunity that informs the selection of future COVID-19 vaccine strains.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines / Variants Language: English Journal subject: Microbiology Year: 2022 Document Type: Article Affiliation country: J.chom.2022.10.012

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines / Variants Language: English Journal subject: Microbiology Year: 2022 Document Type: Article Affiliation country: J.chom.2022.10.012