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COVID-19 and its genomic variants: Molecular pathogenesis and therapeutic interventions.
Manna, Pulak R; Gray, Zackery C; Sikdar, Malabika; Reddy, Hemachandra.
  • Manna PR; Department of Internal Medicine, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, TX 79430, USA.
  • Gray ZC; Department of Internal Medicine, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, TX 79430, USA.
  • Sikdar M; Department of Zoology, Dr. Hari Singh Gour Vishwavidyalaya, Sagar, MP 470003, India.
  • Reddy H; Department of Internal Medicine, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, TX 79430, USA.
EXCLI J ; 21: 1196-1221, 2022.
Article in English | MEDLINE | ID: covidwho-2082728
ABSTRACT
Coronavirus disease-19 (COVID-19), caused by a ß-coronavirus and its genomic variants, is associated with substantial morbidities and mortalities globally. The COVID-19 virus and its genomic variants enter host cells upon binding to the angiotensin converting enzyme 2 receptors that are expressed in a variety of tissues, but predominantly in the lungs, heart, and blood vessels. Patients afflicted with COVID-19 may be asymptomatic or present with critical symptoms possibly due to diverse lifestyles, immune responses, aging, and underlying medical conditions. Geriatric populations, especially men in comparison to women, with immunocompromised conditions, are most vulnerable to severe COVID-19 associated infections, complications, and mortalities. Notably, whereas immunomodulation, involving nutritional consumption, is essential to protecting an individual from COVID-19, immunosuppression is detrimental to a person with this aggressive disease. As such, immune health is inversely correlated to COVID-19 severity and resulting consequences. Advances in genomic and proteomic technologies have helped us to understand the molecular events underlying symptomatology, transmission and, pathogenesis of COVID-19 and its genomic variants. Accordingly, there has been development of a variety of therapeutic interventions, ranging from mask wearing to vaccination to medication. This review summarizes the current understanding of molecular pathogenesis of COVID-19, effects of comorbidities on COVID-19, and prospective therapeutic strategies for the prevention and treatment of this contagious disease.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines / Variants Language: English Journal: EXCLI J Year: 2022 Document Type: Article Affiliation country: Excli2022-5315

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines / Variants Language: English Journal: EXCLI J Year: 2022 Document Type: Article Affiliation country: Excli2022-5315