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Cutaneous manifestations of COVID-19: Report of three cases and a review of literature.
Sachdeva, Muskaan; Gianotti, Raffaele; Shah, Monica; Bradanini, Lucia; Tosi, Diego; Veraldi, Stefano; Ziv, Michael; Leshem, Eyal; Dodiuk-Gad, Roni P.
  • Sachdeva M; Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
  • Gianotti R; Institute of Dermatological Sciences, University of Milan, Italy; Department of Pathophysiology and Transplantation, Università degli Studi, Foundation IRCCS, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Shah M; Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
  • Bradanini L; Department of Biomedical and Clinical Sciences "Luigi Sacco", University of Milan, Italy.
  • Tosi D; Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, Milan, Italy.
  • Veraldi S; Department of Pathophysiology and Transplantation, Università degli Studi, Foundation IRCCS, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Ziv M; Dermatology Department, Emek Medical Center, Israel.
  • Leshem E; Institute for Travel and Tropical Medicine, Sheba Medical Centre, Israel; School of Medicine, Tel Aviv University, Israel.
  • Dodiuk-Gad RP; Dermatology Department, Emek Medical Center, Israel; Bruce Rappaport Faculty of Medicine, Technion - Institute of Technology, Israel; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address: rdodiukgad@gmail.com.
J Dermatol Sci ; 98(2): 75-81, 2020 May.
Article in English | MEDLINE | ID: covidwho-208374
ABSTRACT

BACKGROUND:

Various cutaneous manifestations have been observed in patients with COVID-19 infection. However, overall similarities in the clinical presentation of these dermatological manifestations have not yet been summarized.

OBJECTIVE:

This review aims to provide an overview of various cutaneous manifestations in patients with COVID-19 through three case reports and a literature review.

METHODS:

A literature search was conducted using PubMed, OVID, and Google search engines for original and review articles. Studies written in the English language that mentioned cutaneous symptoms and COVID-19 were included.

RESULTS:

Eighteen articles and three additional cases reported in this paper were included in this review. Of these studies, 6 are case series and 12 are case report studies. The most common cutaneous manifestation of COVID-19 was found to be maculopapular exanthem (morbilliform), presenting in 36.1% (26/72) patients. The other cutaneous manifestations included a papulovesicular rash (34.7%, 25/72), urticaria (9.7%, 7/72), painful acral red purple papules (15.3%, 11/72) of patients, livedo reticularis lesions (2.8%, 2/72) and petechiae (1.4%, 1/72). Majority of lesions were localized on the trunk (66.7%, 50/72), however, 19.4% (14/72) of patients experienced cutaneous manifestations in the hands and feet. Skin lesion development occurred before the onset of respiratory symptoms or COVID-19 diagnosis in 12.5% (9/72) of the patients, and lesions spontaneously healed in all patients within 10 days. Majority of the studies reported no correlation between COVID-19 severity and skin lesions.

CONCLUSION:

Infection with COVID-19 may result in dermatological manifestations with various clinical presentations, which may aid in the timely diagnosis of this infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Skin / Skin Diseases, Viral / Coronavirus Infections / Betacoronavirus Type of study: Case report / Diagnostic study / Prognostic study / Reviews Limits: Aged / Female / Humans Language: English Journal: J Dermatol Sci Journal subject: Dermatology Year: 2020 Document Type: Article Affiliation country: J.jdermsci.2020.04.011

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Skin / Skin Diseases, Viral / Coronavirus Infections / Betacoronavirus Type of study: Case report / Diagnostic study / Prognostic study / Reviews Limits: Aged / Female / Humans Language: English Journal: J Dermatol Sci Journal subject: Dermatology Year: 2020 Document Type: Article Affiliation country: J.jdermsci.2020.04.011